Nitric Oxide and Zinc—Conspirators in Cell Death
Who would have thought that nitric oxide (NO) and zinc (Zn+) act in concert to activate apoptosis? That's the conclusion Stuart Lipton and colleagues propose in a report in the February 5 Neuron...
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Who would have thought that nitric oxide (NO) and zinc (Zn+) act in concert to activate apoptosis? That's the conclusion Stuart Lipton and colleagues propose in a report in the February 5 Neuron...
Researchers in South Korea have apparently cloned the first human embryo. Perhaps equally significant, they have also extracted pluripotent stem cells from the embryo at the blastocyst stage...
Check out the newest gene microarray results in the Alzheimer's brain, and see if they give a lift to some of our favorite hypotheses and molecular suspects...
The quest to unveil the mystery of memory and synaptic plasticity—for some years the domain of behavioral biologists and electrophysiologists—has led scientists squarely back to basic molecular biology...
In this month’s Nature Genetics, MIT researchers suggest that each of the billions of neurons in the human brain may also have its own unique address—courtesy of alternative splicing...
One bit of reassuring evidence tempered the dismay over the encephalitis cases that ended dosing in the phase 2 trial of an Aβ vaccine: At least the vaccine removed the plaques. Not so fast...
Two papers in tomorrow's Science describe genetic maps that may prove useful for studying the genetic basis for human disease...
Activation of PPARγ's cousin PPARδ may spur the development of intestinal cancers in mice, according to a report in the February Nature Medicine...
If you want to make sure to remember something, sleep on it. Sleep research confirms this adage, and indeed, its chemical underpinnings may have surprising implications for Alzheimer’s disease treatment...
Elderly men with symptoms of ataxia and intention tremor may actually have a disorder related to fragile X syndrome, a common form of mental retardation in children. These men show signs of...
Alzheimer's researchers sneak regular peeks over the shoulders of colleagues working on Parkinson's and other neurodegenerative diseases. Why not do the same with schizophrenia researchers, who are working in a disease that features...
Which is more dangerous, the cellular (PrPc) or the infectious (PrPSc) prion protein? Until recently, this would have been easy to answer. But evidence is growing that...
A nifty instrument for mapping the 3-D shape of macromolecular surfaces, the atomic force microscope (AFM) over the last five years has become an established method of measuring how environmental conditions affect Aβ fibril formation as well as...
Cholesterol and lipoproteins, particularly ApoE, are two known risk factors for idiopathic Alzheimer’s disease. But despite numerous reports, scientists’ understanding of how they influence the disease process remains vague...
While it is generally accepted that PS1 has eight transmembrane domains (8-TM), a paper in this week’s early online PNAS resurrects the hypothesis that PS1 assumes a 7-TM topology, and suggests it may have a role...