Anticoagulants for Alzheimer’s?
If aggregates of the sticky amyloid-β can contribute to the pathology of Alzheimer’s disease (AD), then maybe unsticking them will help reverse the process...
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Transdifferentiation—Alive Again?
May 1 2004. Cells of the blood lineage, introduced into patients receiving bone marrow transplants, are reported to have given rise to brain cells. The finding reawakens hope that stem cells from diverse organs may one day be used to repair damage in other types of tissue...
NO Parkin—A Simple Modification Arrests Ligase
The clamp, the boot, whatever you call it, if you find one on your car you’ll appreciate how a seemingly small attachment can keep its wheels from turning. In today’s Sciencexpress, researchers report that covalently clamping parkin with nitric oxide...
"Meet You on the Raft!"—Aβ Rallying Cry?
Do solitary Aβ peptides begin their journey toward insoluble plaques by meeting up with partners on lipid rafts in the plasma membrane? Researchers report evidence that, in an APP-transgenic mouse model, Aβ dimerizes in the rafts and, what's more...
Spinal Tap Dance—Do Myelin-Reactive T cells Protect or Destroy?
Priming the immune system to recognize and clear endogenous antigens from the nervous system has always been a controversial therapeutic strategy. We only have to look to...
ABAD, aka ERAB: Mitochondrial Miscreant Returns
The Aβ-binding alcohol dehydrogenase (ABAD) forms a complex with Aβ in mitochondria, promoting leakage of free radicals, mitochondrial dysfunction, and cell death...
ALS—Bridging the Way to Therapy
Designed to speed transport and communication, bridges may also be useful for slowing disease. Researchers suggest as much in their review of one promising strategy for slowing the progression of ALS...
Dora Kovacs Reports from IBC Conference in San Diego
Last month, the commercial conference planner IBC Screentech held a conference on drug development approaches in neurodegeneration in San Diego, California, as part of its World Summit series...
Pink Mutations Link Parkinson’s Disease to Mitochondria
Mutations in Pink1, a gene coding for a mitochondrial protein kinase, has just been fingered as a genetic cause for parkinsonism. In today’s Sciencexpress, researchers report that Pink1 and PARK6, a long-sought-after genetic locus that is linked with early-onset Parkinson’s disease, are...
Polyglutamine—Gristle for the Proteasome Mill?
Anyone who has minced beef knows that the grinder occasionally gets clogged by a particularly tough bit of meat or gristle. Polyglutamine (polyQ) stretches, it turns out, may have a similar effect on our intracellular protein grinder, the proteasome...
How Much Aβ is Enough?
When it comes to the biological activity of Aβ, a question often pondered is: How much is enough? In the March 31 Journal of Neuroscience, Barry Festoff and colleagues suggest that the answer may be...
What the Fly Forgot—Aβ Expression in Drosophila
A transgenic <em>Drosophila</em> model of AD shows learning deficits, reduced lifespan, amyloid buildup, and neurodegeneration in response to expression of human Aβ42...
Gabrielle Strobel Interviews John Morris
Gabrielle Strobel Interviews John Morris
To Prime the Progenitor Pump, Put Some Endothelium in the Tank
To make a brain from the first neural progenitor, that cell has to divide to give many progenitors, then a portion of these go on to form neurons. It is unclear how...
It's Raining Genomes: Two Human Chromosomes and a Whole Rat
This past week saw big news in genomic sequencing. In separate papers in Nature, human chromosomes 13 and 19 and a draft genome of the storied <em>Rattus norvegicus</em> were unveiled...
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