Mutant Huntingtin—Trojan Horse or Trebuchet?
Mutant proteins that cause neurodegenerative disease, such as amyloid-β precursor protein, parkin, and huntingtin, are produced in many different neurons of the brain. So why do only...
6400 RESULTS
Sort By:
Mutant proteins that cause neurodegenerative disease, such as amyloid-β precursor protein, parkin, and huntingtin, are produced in many different neurons of the brain. So why do only...
Mice live longer and show signs of delayed aging when they express the antioxidant enzyme...
Amyloid-β (Aβ) comes in many forms, including monomers, oligomers, protofibrils, and fibrils. Protofibrils have emerged as perhaps the most...
Originally, vaccination with amyloid-β (Aβ) peptides aimed to fight Alzheimer disease by...
The development of neurotrophic factors for treatment of Alzheimer disease (AD) and other neurodegenerative disorders has proceeded in fits and starts, in no small part due to...
With the exception of familial cases, which can be traced to specific mutations, it is unclear why there’s a glut of...
Though microglia, the housekeeping cells of the central nervous system, have been implicated in the clearance of amyloid-β...
Tom Fagan Interviews Bud Kukull
Last January, Johnson & Johnson announced that the FDA was reviewing safety data on galantamine hydrobromide...
Cases of inherited Parkinson disease, while rare, have been eagerly studied for clues to causes of the far more prevalent sporadic form of the disease. So far...
Is the glass half empty or half full? Alzheimer disease clinicians might be asking themselves that question after seeing the long-awaited results of...
A new approach to immunotherapy for Alzheimer disease (AD) took center stage Tuesday afternoon at the American Academy of Neurology meeting in Miami...
Navigational failure is the rock on which many a traveler has perished. It may also be the reason why many spinal cord neurons...
Genetic mutations are the root cause of many neurodegenerative disorders, including familial Alzheimer and Parkinson diseases. Because most of these mutations...
Huntington disease is a neurodegenerative disorder caused by the repetition of a cytosine-adenine-guanine (CAG) trinucleotide coding for the amino acid glutamine. The repeat occurs in...