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Surveying the protein profile of a tissue or body fluid by traditional methods has not proven a very efficient way to detect changes in protein levels in neurodegenerative diseases...
Since the discovery that one peptide, amyloid-β, is the major constituent of amyloid plaques, there has been a tremendous focus on the N-terminal end of amyloid-β precursor protein...
Fragile X mental retardation, the most common form of inherited mental impairment, is caused by mutations in the fmr-1 gene, coding for fragile X mental retardation protein...
Imagine being able to turn on and off an individual neuron remotely—without prodding it with electrodes or challenging it with chemicals. Sound like a neuroscientist's dream?...
Defeating the yokozuna, the highest ranked professional sumo wrestlers, is almost impossible. Stopping sumoylation, the modification of proteins with small ubiquitin-like modifiers (SUMO) may be easier...
Phosphorylation of the microtubule-associated protein tau may be a good thing because it can speed up microtubule transport, but abnormal phosphorylation...
Television shows about medical examiners and psychological profilers are all the rage these days. Wouldn't you like to see one about “cytological” profilers?...
As many of our readers are aware, there has been a running court battle between Elan Inc., Dublin, Ireland, and the Mayo Foundation for Medical Education and Research...