Mismatch Between Gene and Protein Sequence Data
The path from identifying a genome sequence to pinpointing the contribution of each gene is beset with pitfalls. In a Brief Communication [in today's Nature], researchers describe discrepancies...
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Ultimate Stem Cell in Adult Bone Marrow?
Stem cells from the bone marrow of adults may be as flexible as embryonic stem cells, according a study in the current issue of Cell. Researchers at Yale, New York University, and Johns Hopkins found that these cells...
Unraveling Metabolic Pathways
In a prime example of what science can accomplish in the "post-genomic" era, researchers have pieced together the functions of a variety of genes involved in a yeast metabolism pathway...
More on a Glial Role in Neuronal Signalling
Two reports in tomorrow's Science add to a growing body of evidence that glial cells play more than a "housekeeping" role and are essential for neuronal signalling...
Mitochondrial Damage in Alzheimer's Disease
A closer look at mitochondria in Alzheimer's disease confirms that oxidative damage to these cellular power plants is a central feature of the disease, according to a report in the May 1 issue of the Journal of Neuroscience...
Lifting Sugar Blockade Leads to Axon Regrowth
A major challenge for achieving nerve regeneration following an injury to the adult brain and spine is the presence of numerous proteins that block the growth of axons across the injury site...
Specific γ-Secretase Inhibitor Synthesized
Researchers from France reported success in synthesizing novel compounds that specifically target γ-secretase cleavage of amyloid-β (Aβ) peptide, without affecting the enzyme's cleavage of other substrates...
Canadian Dapsone Trial Halted
Immune Network Ltd. reported last week that the company's Canadian Phase I clinical study has been halted due to an unexplained...
Heart Repair by Bone Marrow-derived Stem Cells
Stem cells from mouse bone marrow can help repair muscle killed in heart attacks, Piero Anversa and his team at New York Medical College, New York, and colleagues, show in [the 5 April issue of] Nature...
fMRI Data Repository Now Open
A team at Dartmouth College, New Hampshire, has developed a brain-image repository that will make it possible for scientists to freely share fMRI data with colleagues worldwide...
Chris Weihl Interviews Sam Gandy
Chris Weihl Interviews Sam Gandy
A Potential Mechanism for Cell Toxicity in Huntington's
The abnormal form of the protein huntingtin may exert its toxic effects on neurons in Huntington's disease by interfering with a protein essential for gene transcription, according to a study published in this week's issue of Science...
Neurogenesis and Memory
It is now generally accepted that new neurons are generated in the adult mammalian brain, but until now it has been unclear whether or not these neurons are essential for memory formation...
Mitochondrial Exports
A British and German team has made the surprising discovery that the cell's mitochondria can export peptides into their surrounding environments. Much is known about how mitochondria import proteins, but the role of this unexpected export mechanism...
Mouse (Gene) Trap
Understanding the mechanisms regulating brain wiring has until now relied on biochemical purification approaches in vertebrates and genetic approaches in invertebrates to identify molecular clues. This week...
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