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Tomorrow's Nature magazine carries an article on head trauma that could inform parts of Alzheimer's research, as well. Esther Shohami at Hebrew University's Medical Faculty in Jerusalem, and colleagues there, report that an endogenous cannabinoid plays a role...
Most cases of amyotrophic lateral sclerosis (ALS) have no familial history that could help researchers home in on genetic causes. About 10 percent of cases are inherited, from which five potential ALS genes have been mapped to independent chromosome regions...
One of the hallmarks of sporadic Parkinson's disease (PD) are Lewy bodies (LB), neuronal cytoplasmic inclusions that contain ubiquitinated proteins. Recently researchers have focused on two key LB components, the 16 kDa α-synuclein, and the ubiquitin-ligase parkin...
The deposition of Aβ has long been implicated in the cellular damage and subsequent cognitive dysfunction of Alzheimer's disease, but the mechanism for this remains unclear...
In tomorrow's Science, Bjorn Falkenburger, Karen Barstow, and Isabelle Mintz of Boston University Medical Center demonstrate a novel mechanism for dopamine release in the substantia nigra (SN)...
The Biology of α-Synuclein and Lewy body Disease Workshop Meeting Cosponsored by NIA and NINDS, Bethesda, Maryland, July 16-17, 2001...
In a feat of miniaturization, researchers have engineered a fluorescence microscope that is three inches long, weighs less than an ounce, and sits perched on a rat's head...
Mutations in the presenilin 1 gene (PS1) are responsible for most cases of early-onset familial Alzheimer's disease (FAD). These mutations are accompanied by an increase in β-amyloid peptides.
The National Institute of Aging has awarded $54M over five years, one of its largest-ever grants, to the Alzheimer's Disease Cooperative Study (ADCS). Directed by Leon Thal at the University of California, San Diego, this consortium of centers...
Investigators working to detect subtle changes in cognitive ability form part of the ongoing effort to develop ways of identifying people who will go on to develop AD in the future...
A cholesterol-modifying enzyme not previously implicated in Alzheimer's disease modifies production of the pathogenic Aβ peptide, report researchers led by Dora Kovacs at Massachusetts General Hospital...
Astrocytes are the stem cells that generate new neurons in the mammalian hippocampus, according to a report in the September 15 Journal of Neuroscience. This result appears to match results from the subventricular zone...
One of the most pressing needs in Alzheimer's research today is the ability to identify, among normal elderly people, those who will likely go on to develop AD. A paper published today...
The dominant theory of Alzheimer's disease is that insoluble aggregates of amyloid-β (Aβ) are the neurotoxic entity that causes neuronal dysfunction and cell death...
Two apparently contradictory reports in the August 11 Lancet have injected new fuel into the debate about the role of inflammation in Alzheimer's disease...
