AMPA Receptors: Going, Going, Gone in Aβ-exposed Synapses, PSD95 Knockouts
One of the earliest signs of amyloid-β (Aβ) toxicity is synaptic loss, and recent work from a number of labs has shown that...
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One of the earliest signs of amyloid-β (Aβ) toxicity is synaptic loss, and recent work from a number of labs has shown that...
The human ApoE4 isoform is the biggest single risk factor for sporadic Alzheimer disease (AD)...
Mutations in presenilin associated with familial Alzheimer disease perturb calcium signaling in cells. In particular, some mutations suppress...
On Monday, federal prosecutors brought criminal conflict of interest charges against...
Dementia strikes in many forms besides Alzheimer disease, and two recent reports take a look at the biochemical basis for dementias in other settings...
Neurons cannot afford to be spineless. Not only are those dendritic protrusions essential for transmitting incoming signals from other neurons, but...
The NAD synthesizing protein nicotinamide mononucleotide adenylyltransferase (Nmnat) got the attention of neuroscience researchers as...
Two new papers reveal how environmental influences can directly affect the activity of the APP-processing enzymes β-secretase (BACE1) and γ-secretase...
When it comes to pathological variations in the human genome, single nucleotide polymorphisms have taken their fair share of the heat...
Many researchers are acquainted with Arc/Arg3.1 as a marker of neuronal activity in the brain. The gene is induced by...
Trauma suffered at an early age can end up taking a toll later in life. Might the same hold true...
SfN Satellite Symposium: Neurotoxic Mechanisms in Alzheimer Disease SfN and More: Two Faces of TGF-β Revealed by Dead End Receptor SfN: Aβ Conformation and Location Figure in Toxicity SfN: The Old and the New—BACE and Cathepsin B Share the β-secretase Sta
A lively platter of slide talks on APP processing and β-secretase (BACE) activities yielded a few interesting tidbits on the...
Perhaps some good can come from the Alzheimer’s Disease Anti-inflammatory Prevention Trial (ADAPT)...
Tuebingen: Researchers Reminisce, Predict at Alzheimer Centennial Tuebingen: The Man Behind the Eponym Alzheimer 100 Centennial