Alzheimer’s Breakthrough Ride Rolls Into Washington
The Alzheimer’s Breakthrough Ride started on 17 July 2010 in San Francisco and culminated yesterday, World Alzheimer’s Day, in Washington, DC...
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Stop! Or I’ll...Ubiquitinate? Ligase Polices Runaway Proteins
Every protein-coding RNA needs a termination codon or translation will run right on through the poly-adenine tail, producing a run of superfluous lysines...
World Alzheimer Report: Care Costs 1.0 Percent of World GDP
The autumnal equinox, when the whole world gets equal time in the sunlight, might be an appropriate time to take a global view of Alzheimer disease...
Learn the Skinny on iPS Cells in Neurodegenerative Disease
Are you curious about trying iPS cell lines to model the disease you care about? Intrigued but nebulous on where the field is at? Ready to grow an iPS line but not sure where to turn? Read Madolyn Rogers's four-part series to learn all about who does
Not So Fast: iPS Cells Have Potential Pitfalls
IPS cells have created excitement among researchers who see them as more available, easier to make, and less ethically conflicted than embryonic stem cells...
Brain Aβ Patterns Linked to Brain Energy Metabolism
What makes some areas of the brain more vulnerable to Aβ? A pair of related papers offer a clue...
Iron Export? New Role Links APP, Metals, to Oxidative Stress
Amyloid precursor protein (APP) exports iron from neurons...
Hereditary Diseases: A Natural Fit For iPSC Modeling
One of the three iPSC consortia funded by the National Institute of Neurological Disorders and Stroke (NINDS) is creating lines for ALS...
DHA Study—Could Alzheimer’s Be a Liver Disease?
New data may inspire some AD researchers to consider expanding their postmortem analyses to include tissue from a curious source—the liver...
In Alzheimer Disease Research, iPS Cells Catch On Slowly
While scientists are steaming ahead on establishing iPSC lines for research into PD and ALS, they have been more reluctant to embrace the technology for AD...
Where in the World Are the iPS Cells?
Since the discovery, in 2006, that adult cells could be reprogrammed to a pluripotent state, scientists have been excited by their potential...
The Plot Thickens: The Complicated Relationship of Tau and Aβ
Researchers are finding that Aβ and tau revolve more closely around each other than they had thought...
New γ-Secretase Modulators Reduce Aβ42, Avoid Notch
Despite recent setbacks on the clinical front, the hunt for small molecules that can cleanly tweak γ-secretase to slow AD seems to be alive and well...
Follow the Calcium—Influx Through NMDARs Releases Yet More From ER
A steady trickle of studies is building the case for mismanaged neuronal calcium as a trigger of synaptic troubles that contribute to Alzheimer disease...
Latest TDP-43 Mouse Unites ALS and SMA Pathways
In motor neuron disease, evidence is mounting that RNA processing lies at the heart of molecular pathogenesis...
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