Prior evidence for protective effect evaporates after adjustment for demographic differences in high- and low-lithium communities.
PET study finds tau signal associated with markers of cerebrovascular disease and cognitive issues.
Not the brown trucks with the friendly delivery guys: UPS as in unconventional protein secretion pathway. Tau rides it to slink out of one cell, and, grabbing onto heparin sulfate proteoglycans, enter another.
The company has halted all trials of atabecestat.
Engineered nanoparticles snatched extracellular Aβ, ferried it into cells, and switched on autophagy, clearing the peptide from the brains of mice. Would this work as a drug?
Contrary to previous findings, both proteins seem to escape via passive diffusion. This has implications for therapeutic strategies to keep them where they belong.
Aggregates that form inside, or just pass through, oligodendrocytes take on the properties of the virulent strain that gives rise to multiple system atrophy.
ApoE4 raises CSF tau more in women than in men, suggesting sex may influence the risk of neurodegeneration, especially in amyloid-positive E4 carriers.
Exposure to lipid membranes embedded with cholesterol accelerate Aβ fibril formation by up to 20-fold.
A large retrospective study in veterans finds that even brain injuries that cause no loss of consciousness come with a twofold higher risk of developing all-cause dementia.
The two datasets reveal almost identical cognitive decline in prodromal AD, the stage targeted by secondary prevention trials.
Even at below threshold levels, cortical amyloid can drive cognitive decline, tau accumulation.
Two tau PET tracers flag brain areas that accumulate tangles, without background labeling in the choroid plexus. However, pesky off-target binding was seen in the meninges.
The antioxidant ebselen promotes disulfides in SOD1, restores dimerization, and prevents protein misfolding.
Biogen showed results from clinical trials of anti-Aβ and anti-α-synuclein antibodies at the American Academy of Neurology annual meeting.