IFITM3 Forges Link Between Neuroinflammation and Aβ Production
The antiviral protein enhances γ-secretase processing of APP. More of it is present in Alzheimer’s disease.
ALL NEWS
5748 RESULTS
Sort By:
- Most Recent
- Most Commented
In Preclinical Alzheimer’s, Learning Falters Before Memory
Learning tests may prove more informative in clinical trials of early AD. A new one claims it can spot a difference in six days.
VCP Coding Mutation Causes a Tauopathy With Vacuoles
Carriers of a rare hypomorphic gene variant develop a frontotemporal dementia that features Alzheimer’s-like neurofibrillary tangles.
In Astrocytes, ApoE4 Bungles Endocytosis, PICALM Picks Up the Slack
The first steps of endocytosis faltered in astrocytes expressing ApoE4, but pumping in PICALM reversed the problem. A new study places two Alzheimer’s risk factors into the same cellular mechanism.
FDA Advisory Committee Throws Cold Water on Aducanumab Filing
The panel considered the evidence for efficacy to be weak, and was troubled by too-close collaboration between the sponsor and the FDA.
Pertussis Toxin Stokes Autoimmune Reaction in Aβ-Vaccinated Mice
In this month’s Brain, researchers at the Universities of Milan and Genoa, Italy, report that immunizing C57/Bl6 mice with Aβ42 generated an inflammatory response similar to an autoimmune disease in the brains of these mice...
Dopamine Renders α-Synuclein Toxic to Neurons
In tomorrow's Nature Medicine, Bruce Yankner at Children's Hospital in Boston offers up a partial explanation for one of the abiding questions in Parkinson's research: Why do neurons die in such a selective pattern?...
Aiding and Abetting, Hyperactive CDK5 Gives Mouse Tangles
Despite its long and distinguished history in Alzheimer’s research, the microtubule-stabilizing protein tau still poses many a riddle to scientists. They do know that excessive phosphorylation of tau somehow figures in neurodegeneration...
Early Clinical Results of Cox 2 Inhibitor: No Pain, No Gain?
randomized trial to test the feasibility of using the COX-2 inhibitor nimesulide as a chronic treatment in Alzheimer's patients...
Presenilins Work Overtime to Control Akt, Tau, and Aβ—n-3 Fatty Acids Aid and Abet
The job description of presenilins (PS) in the business of neuron health and disease may be getting more complicated...
Aβ Assault on Neurons Targets ER, Calcium
When it works properly, the endoplasmic reticulum (ER) constantly pumps out newly synthesized membrane proteins, perfectly folded and sorted to their proper cellular destination...
Amyloid-β Zaps Synapses by Downregulating Glutamate Receptors
The amyloid-β (Aβ) peptide is a destroyer of synapses, and its attack on neurotransmission is blamed for devastating...
Neurotoxic Homocysteine Metabolite Boosts Intracellular Aβ
The epidemiologic link between elevated blood homocysteine (HC) and Alzheimer disease has spurred the search for the mechanisms by which...
ADNI: One-year Data Narrow Field of MRI, FDG-PET Approaches
Alzheimer imaging aficionados gathered for a peek at the latest data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI)...
The Toxic Fold? Aβ Dodecamers, Tetramers Show Their Conformations
Amyloid-β (Aβ) peptide oligomers have come under intense scrutiny as the prime suspects in the synapse loss and neurotoxicity associated with Alzheimer disease...
Current Filters
- Date Range : All x