Siphoning off the Toxic Humors: CSF Shunts in AD
The progression of Alzheimer's disease might be slowed by draining cerebrospinal fluid from the brain, according to pilot data in AD patients...
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The progression of Alzheimer's disease might be slowed by draining cerebrospinal fluid from the brain, according to pilot data in AD patients...
Crumbling microtubules, those slender filaments that aid a variety of cellular processes from cell division to vesicle trafficking, could lead to motor neuron disease...
Evidence has grown over the last few years for the involvement of the tumor suppressor protein p53 in the neuronal cell death that accompanies a variety of neurodegenerative diseases, including Alzheimer's disease...
Condensed matter physics to the rescue! Researchers use a fresh approach to tackle the old question whether amyloid plaques are toxic.
A gene known to cause a rare form of familial Parkinson's disease codes for 2 separate and opposing enzyme activities, both of which affect the degradation and accumulation of proteins such as α-synuclein, researchers report.
Could α-synuclein play a role in mobilizing the synaptic vesicle reserves during intense stimulation? Read about Robert Nussbaum's latest findings.
Read about this new mechanism proposed to explain the pathogenesis of prion diseases. Featured in "In the Spotlight" on our homepage.
Worries over side effects of γ-secretase inhibitors due to their unwanted effect on Notch cleavage might ease a little with a report demonstrating that the two cleavage events may be regulated at least partly independently. Certain nicastrin mutations affect only Notch cleavage, not AβPP cleavage.
Two papers advance the drive to develop an Alzheimer's vaccine, one looking at the antibody response in some of the Elan trial participants, the other using sophisticated methods to analyze the epitope recognized by antibodies generated in response to Aβ42 immunization.
Using gene therapy to boost production of the inhibitory neurotransmitter GABA has produced marked improvements in a rat model of Parkinson's....
In today's PNAS early edition, researchers report that transgenic mice devoid of the protein α-synuclein are resistant to MPTP, a neurotoxin that induces Parkinson-like symptoms....
Can PET improve on the battery of tests that are already in use to diagnose Alzheimer's. A new study shows that imaging analysis decreases the number of false negatives by five percent and the number of false positives by more than 10 percent...
A mutation in mice that causes ataxia, or muscle paralysis, has been identified as an insertion of 5.2 kb of DNA in the gene for ubiquitin-specific protease 14 (Usp14)....
Less than two weeks after announcing that memantine had shown significant benefit in a clinical trial of patients with moderate to severe Alzheimer's disease, Forest Laboratories announced that they have withdrawn their New Drug Application with the FDA...
Fluorescence imaging has become a powerful tool for measuring protein mobility and is particularly suited to probing the dynamics of protein-protein interactions in inclusion bodies....
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