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Society for Neuroscience Annual Meeting: Stem Cells Drawn to Aβ Society for Neuroscience Annual Meeting: Stem Cells Promising for Motor Neuron Disorders Society for Neuroscience Annual Meeting: Does ApoE Contribute to Tangle Formation? Society for ...
The 40th ASCB meeting began its grand kick-off on Saturday December 9 with an opening symposium by four Nobel Laureates, J. Michael Bishop, Joseph Goldstein, Michael Brown, and Harold Varmus. Bishop summarized his discovery of proto-oncogenes...
A trio of articles will appear in tomorrow's issue of Nature, reporting that Aβ peptide immunization reduces a memory deficit in transgenic mouse models of AD...
The molecular and genetic mechanisms involved in the initiation and progression of Alzheimer’s disease (AD) are poorly understood. One emerging player in the proinflammatory cycle operating in AD brain...
Widespread reports of changes in RNA message abundance and specific RNA message levels in senescent cultured primary neural cells, in normal aging human brain and especially in Alzheimer’s disease-afflicted neocortex and hippocampus suggest...
Bertram et al. (301.7), evaluated Alzheimer’s disease (AD) candidate genes and AD chromosomal regions of interest (`30 cM) from the whole genome scans available...
The presenilin-1 and -2 (PS1, PS2) genes encode integral transmembrane proteins putatively involved in cell-cell recognition, cell-fate determination, intercellular signaling and Aβ peptide formation...
Presenilin-1 and -2 (PS1, PS2) gene mutations appear to cause the majority of cases of early-onset familial Alzheimer’s disease (EO-FAD). In this presentation Potter et al. (492.2) presented data...
Presenilin-1 and -2 (PS1 and PS2) are members of a (growing) family of genes which encode polytopic integral transmembrane proteins homologous to the Notch cell surface receptors of <em>Drosophila</em>...
Two immune proteins found in the brains of mice help the brain develop and may play key roles in triggering developmental disorders like dyslexia and neurodegenerative disorders like Parkinson's disease...
Mutations in the genes for α-synuclein and parkin have been linked to early-onset Parkinsonism, but the role of genetics in the far more common late-onset disease has been less clear...
Undifferentiated cells from the adult spinal cord can generate neurons when transplanted to the adult hippocampus, reveal Fred Gage and his coworkers at the Salk Institute, California, in the current issue of the Journal of Neuroscience...
The meeting in New Orleans demonstrated that the biology of α-synuclein and parkin are progressing at a rapid pace...
Macrophage activity is thought to play a key role in Alzheimer's and some other neurodegenerative diseases, such as ALS, as well as in autoimmune disorders. The mechanisms that regulate macrophages could...
Statins have recently appeared on the radar screen for Alzheimer's researchers because of studies by Ben Wolozin and his colleagues showing that people who take the cholesterol-lowering drugs have a significantly reduced risk of Alzheimer's disease...
