Keystone: TBI—Learning From Markers, Models, and Diseases
Injury to the brain, even what might be considered mild, can have devastating consequences on brain physiology...
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Boost APP Ubiquitination, Wnt Signaling to Stave Off AD?
The prevailing theory that Aβ peptides are a major culprit in Alzheimer’s disease offers no shortage of possible therapeutic approaches...
San Diego: Tau Oligomer Antibodies Relieve Motor Deficits in Mice
Mirroring a trend in amyloid-β research, work on the tau protein seems to be moving from tangles toward that infamous “O” word—oligomers...
San Diego: Pilin’ on the Pyro, Aβ Going Rogue
What causes Aβ to go rogue in Alzheimer’s disease?...
San Diego: Aβ Oligomers Seen, With ApoE, at Synapses of Human Brain
Despite decades of research, it is still not clear how apolipoprotein E ties in with AD etiology...
San Diego: The Curious Case of ApoE, Cholesterol, and Cognition
Evidence for cholesterol’s role in Alzheimer’s disease has been growing in recent years, and many cardiovascular risk factors have popped up also...
Tau Modification—Move Over Phosphate, Make Room for Acetylation
Researchers report that tau is acetylated in vitro, in cell culture, in a mouse tauopathy model, and in several human tauopathies...
Taos: Not the Usual Suspects: PARIS et al. Mark Progress in PD
Researchers are finally getting a grip on the long-suspected link between mitochondria and not only PD, but other neurodegenerative diseases as well...
San Francisco: Gladstone Institute Hosts Tau Powwow
In San Francisco, attendees discussed how tau goes awry...
San Francisco: Tau—Time to Shine as Therapeutic Target?
Attendees bonded over a common research interest—the protein tau and its role in neurodegeneration...
Making (Anti)sense of Rare Huntington’s Variant
Like HD sufferers, rare individuals with Huntington’s disease-like 2 (HDL2) have the same type of genetic mutation...
Is Motor Neuron Troublemaker Just a Bad Driver?
The protein survival of motor neuron (SMN), whose absence causes spinal muscular atrophy, has a new charge: an mRNA needed to make neuromuscular junctions...
Uppsala: Is Tau Immunotherapy Taking Off?
Targeting extracellular Aβ with immunotherapy is one thing, but could antibodies even drive the clearance of tau, a predominantly intracellular protein?...
Uppsala: Immunotherapy—Not Just for AD Anymore
As immune-based therapies targeting Aβ and tau are beginning to show promise for the treatment of Alzheimer’s, what about other disorders of the nervous system?...
ALS: Mutant Enzyme Does Not Hang Around, But Does Find Mitochondria
Although it seems that many deficiencies can lead to ALS, the enzyme SOD1 has long received the lion’s share of attention...
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