ACAT and Mouse—Inhibiting Former Prevents AD-like Pathology in Latter
Inhibiting ACAT, a cholesterol-modifying enzyme, may prove a viable therapy for preventing or slowing the progression of Alzheimer disease...
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Tau Kinase Clears Microtubules—Keeps Axonal Transport on Track
Microtubule affinity regulating kinases (MARKs) regulate transport along axonal microtubules by pulling microtubule-associated proteins, including tau, off the tracks...
Caught in the Act—Amyloid Damages Neurons
Since Alois Alzheimer’s first descriptions of senile plaques, we have known that they are associated with dementia. But are they detrimental?...
New Microscope Resolves Role of Huntington Inclusions—Neuroprotection
Inclusion bodies: Grim reapers or guardian angels? A robotic microscope, which can monitor the health of hundreds of neurons infected with mutant huntingtin, has the answer...
DJ Chaperones α-Synuclein—Offers Cell Model of Parkinson Disease
New evidence suggests that DJ-1, which is mutated in some cases of early-onset Parkinson disease, acts as a chaperone that prevents aggregation of...
American Neurological Association: 2004 Annual Meeting
End of the Road for GDNF Parkinson Therapy—or Just a Detour? American Neurological Association: 2004 Annual Meeting
End of the Road for GDNF Parkinson Therapy—or Just a Detour?
Infusing GDNF directly into the striatum of Parkinson disease patients fails to prevent functional decline...
Neuron Refreshes Our Memory
A special section in the September 30 Neuron reviews some of the advances made in understanding the processes involved in learning, storing, and recollecting information...
Remote Healing by Stem Cell-Derived GDNF?
Recent reports suggest that human umbilical cord blood cells can rescue brain neurons damaged by stroke. But curiously, the blood cells don’t have to enter the brain to be effective...
Merck Withdraws Vioxx®
Pharmaceutical giant Merck announced today that it was withdrawing rofecoxib, a pain and antiinflammatory drug, from worldwide markets...
PPARγ Partner PGC-1α Linked to Huntington Disease-Like Symptoms
PPARγ has received a lot of attention from neuroscientists lately. Now, ablation of one of its partners, PGC-1α, has been found to cause...
FRETting Pays off—NSAIDs Target Presenilins, Reduce Aβ42
Some NSAIDs have been shown to shift Aβ production to the shorter Aβ1-38. Now, results suggest that they do this by eliciting a conformational change in presenilin...
Researchers Catch GIT1 in Huntingtin Fishing Net
Researchers demonstrate the power of combining cDNA and yeast two-hybrid (Y2H) screens in pursuit of protein accomplices of disease-suspect molecules, in this case...
Neurobiology of Aging to Publish Negative Results—Call for Manuscripts
Paul Coleman, as editor-in-chief of Neurobiology of Aging, has initiated a policy of accepting negative results for publication...
Protofibrils Permeabilize Lipid Membranes
How are protofibrils toxic? An accelerated publication suggests that they permeabilize and increase the flux of ions across lipid bilayers...
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