Paper Alert: Mass Spec of Tau Points to Ubiquitination
A study first summarized in our SfN conference news, on post-translational modifications of the protein tau, appeared in JBC online...
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Ataxia—Rare Spectrin Mutations and a Rarer Pedigree
Spinocerebellar ataxias (SCAs) are a group of inherited neurodegenerative diseases that...
Niche News: New Pathways Link Stem Cells and the Nervous System
Researchers studying brain development have identified a key transcription factor that drives...
Dangerous Liaisons—Tau and Aβ, Together at Last?
They are no match made in heaven, but in neurons, the two proteins responsible for amyloid plaques and neurofibrillary tangles might...
Dendritic Spine Research—Putting Meat on the Bones
Dendritic spines are rapidly becoming the darling of neuroscientists...
Science Retracts Stem Cell Papers, Fallout Continues
Last week, the journal Science formally retracted two stem cell papers published by Woo Suk Hwang and colleagues...
Do Kinder, Gentler T Cells Promote Neurogenesis?
Raging autoimmune T cells were fingered as the culprits in the toxicity of the failed first-generation Alzheimer disease (AD) vaccine. Even so...
New Name for ISOA
The <a href="http://www.aging-institute.org" target="_new">Institute for the Study of Aging</a> (ISOA), Ltd. has changed its name to...
AD Pathology—Loss of Kinase Sends Synapses PAKing
Reduced activity of p21-activated kinase (PAK) may cause the synaptic defects that leave Alzheimer patients with poor memory and cognitive skills...
Mouse of a Different Color: Presenilin Mutations Affect Melanin
As the roster of substrates for the γ-secretase protease continues to swell, the presenilin (PS) proteins seem to be...
Memantine—Good for a Year, But Little Disease Modification
The drug memantine is a safe and effective therapy that helps patients suffering from moderate to severe Alzheimer disease for up to a year. However...
Neuronal Plasticity the Arbor Way—Dendritic Remodeling in the Neocortex
The word "plasticity" means different things to different people. One of its common uses refers to...
Brain Imaging Speaks Volumes about AD and the Aβ Sink
A paradox has plagued Alzheimer disease (AD) researchers for quite some time: People with AD have...
Huntingtin and Transcription: A Story of the Incredible Shrinking CAG Repeats
The genetic expansion of internal polyglutamine sequences in several proteins renders them...
Passive Aggressive—Must Antibody Therapy Start Early to Be Effective?
Ever since encephalitis halted development of Elan’s active vaccine for Alzheimer disease...
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