Do Perivascular Macrophages Mediate Aβ Pathology?
Researchers implicate these innate immune cells in the disruption of neurovascular coupling by Aβ in mice.
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Trigger Warning: α-Synuclein Sets Off T Cells in Parkinson’s
White blood cells from certain Parkinson’s patients react to α-synuclein peptides. Is this autoimmune reaction why the major histocompatibility complex is genetically linked to the disease?
Ring Around the Vessel: Enlarged Spaces Signal Vascular Disease
Gaps surrounding blood vessels in the brain may predict cognitive decline and vascular dementia.
As Youth Fades, So Does the Fire of Glycolysis in the Brain
The aging brain winds down rapid glucose metabolism in regions that will go on to accumulate amyloid, perhaps raising the risk of neurodegeneration.
Can Biomarker Data Predict Individual Risk for Alzheimer’s?
Researchers debut a statistical model that uses MRI, CSF, and demographic data to compute a cognitively impaired person’s risk for progressing to dementia.
How Does a Neuron Avoid Aggregation of Liquid Protein Droplets?
Mutations spur fibrillization, while methylation and autophagy keep droplets nice and fluid.
Lack of C9ORF72 Protein Renders Neurons More Vulnerable to Degeneration
A new study provides the first solid evidence for a loss-of-function mechanism in ALS caused by C9ORF72 repeat expansions.
Treat IBD, Dodge PD? Epidemiology Ties Parkinson’s to Inflammation
People with inflammatory bowel disease are at higher risk for Parkinson’s—but not if they take anti-inflammatory medication.
No, TDP-43 and FUS Are Not Actively Exported From the Nucleus
Contrary to previous findings, both proteins seem to escape via passive diffusion. This has implications for therapeutic strategies to keep them where they belong.
Senate Approves $2.34 Billion Budget for Alzheimer’s Research
The 2019 budget ups this year’s spending by $425 million.
New Mouse Models Reveal Unexpected Property of TREM2
The shed domain of this microglia receptor sticks to plaques and neurons. Not so for the R47H AD variant, however.
Long Live the Microglia! Studies Trace Their Lifespans in Mice and Humans
About half of microglia in the mouse brain live as long as the whole mouse, while those in the human brain live, on average, just over four years. How does this change in Alzheimer’s?
Microglia Prune Synapses in a Subtype of Frontotemporal Dementia
On the heels of news that microglia mediate synaptic loss in Alzheimer’s, researchers report they may do the same in a subtype of FTD caused by progranulin deficiency.
New Therapeutic Idol? Silencing Ligase Prevents Aβ Deposition in Mice
Without the E3 ubiquitin ligase Idol, microglia readily gobble up ApoE and Aβ in a mouse model of Alzheimer’s disease.
ApoE’s Secret Revealed? Protein Promotes Aβ Degradation
Despite its spot on top of the pile of genetic risk factors for late onset AD, ApoE has remained an enigma on the pathophysiological level...
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