Lack of C9ORF72 Protein Renders Neurons More Vulnerable to Degeneration
A new study provides the first solid evidence for a loss-of-function mechanism in ALS caused by C9ORF72 repeat expansions.
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Treat IBD, Dodge PD? Epidemiology Ties Parkinson’s to Inflammation
People with inflammatory bowel disease are at higher risk for Parkinson’s—but not if they take anti-inflammatory medication.
No, TDP-43 and FUS Are Not Actively Exported From the Nucleus
Contrary to previous findings, both proteins seem to escape via passive diffusion. This has implications for therapeutic strategies to keep them where they belong.
Senate Approves $2.34 Billion Budget for Alzheimer’s Research
The 2019 budget ups this year’s spending by $425 million.
New Mouse Models Reveal Unexpected Property of TREM2
The shed domain of this microglia receptor sticks to plaques and neurons. Not so for the R47H AD variant, however.
Long Live the Microglia! Studies Trace Their Lifespans in Mice and Humans
About half of microglia in the mouse brain live as long as the whole mouse, while those in the human brain live, on average, just over four years. How does this change in Alzheimer’s?
Microglia Prune Synapses in a Subtype of Frontotemporal Dementia
On the heels of news that microglia mediate synaptic loss in Alzheimer’s, researchers report they may do the same in a subtype of FTD caused by progranulin deficiency.
New Therapeutic Idol? Silencing Ligase Prevents Aβ Deposition in Mice
Without the E3 ubiquitin ligase Idol, microglia readily gobble up ApoE and Aβ in a mouse model of Alzheimer’s disease.
ApoE’s Secret Revealed? Protein Promotes Aβ Degradation
Despite its spot on top of the pile of genetic risk factors for late onset AD, ApoE has remained an enigma on the pathophysiological level...
ABCA1 Links Cholesterol and ApoE, But It May Not Be a Risk Factor for AD
Independent labs report that the cholesterol transporter ABCA1 keeps brain ApoE levels high and saturated with cholesterol, but a third paper casts doubt on the link between the transporter and AD...
Smoking Debate Still Smolders
Everyone knows that smoking is bad for you. But there is some evidence, both epidemiological and molecular, that smokers are at reduced risk for neurodegenerative diseases such as Alzheimer's (AD) and Parkinson's (PD)...
Lifestyle Coaching Slows Cognitive Decline in African-Americans with MCI
A behavioral intervention slowed memory slippage and functional decline over two years.
Across Time and Space: Machine Learning Reveals Paths to Dementia
Analysis of MRI brain volume data identifies multiple AD and FTD/ALS disease subtypes with distinct patterns of degeneration over time.
Crystal Structure of Aβ and Proposed Receptor Solved
A small molecule that protects neurons fends off a short region of Aβ from a specific pocket on the LilrB2 receptor.
Aggregation-Prone Gene Expression Signature Mapped in Brain
Profile matches Braak staging regions, suggesting those areas are particularly susceptible to AD pathology.
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