Recent conferences revealed that tau is most toxic in oligomeric form, that tau oligomers propagate throughout the brain, and that tau oligomers might harm synapses from within or via astrocytes.
At SfN, some scientists described how circulating immune cells deliver aging to the mouse hippocampus; others held off parkinsonism by blocking the effects of eotaxin’s rise in blood. Human trials are starting.
The material, previously used to treat children with growth deficiencies, triggered amyloid deposition in transgenic mice.
Case study in early onset AD finds PET ligand tracks regional tau burden.