No Toxicity in Tau’s Tangles?
In Alzheimer and some other neurodegenerative diseases, the microtubule-associated protein tau weaves a web of neurofibrillary tangles (NFTs) that might...
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Statin Use and Alzheimer Disease: A Tale of Two Methodologies?
Depending on how you slice the epidemiological pie, the use of cholesterol-lowering statins could appear to...
Linking APP to Apoptosis—p53 Does the Trick
The tumor suppressor and apoptotic transcription factor p53 has been linked to Alzheimer disease in numerous ways, but perhaps the most direct link is...
A Homeo Run for the Vascular Hypothesis?
The vascular hypothesis of Alzheimer disease suggests that pathology starts with hypoperfusion, or decreased blood flow to the brain...
What Do Clinicians Say? Peers Welcome Revised Criteria
A comprehensive proposal of new diagnostic criteria marked a highlight at the International Conference on Alzheimer’s Disease...
Honolulu: The Missing Link? Tau Mediates Aβ Toxicity at Synapse
For the first time, a paper details a molecular mechanism that links tau to Aβ toxicity at the synapse...
New Gene for ALS: RNA Regulation May Be Common Culprit
Scientists have uncovered a fresh clue in the mystery that is amyotrophic lateral sclerosis...
Hyperactive Neurons and Amyloid, Side by Side
Experimental evidence and plain common sense tell us that neurons lose activity in Alzheimer disease...
Ironing out the Role of Metals in Neurodegenerative Diseases
A large, collaborative group led by Julie Andersen at the Buck Institute for Research in Aging, Novato, California, demonstrates that lowering the bioavailability of iron—both systemically and in dopaminergic neurons—protects mice against chemically induced Parkinson's...
Smuggling Antibodies to BACE Across the Blood-Brain Barrier
The tight barrier between brain and blood vessels guards the brain from harm, but also frustrates scientists trying to deliver therapeutic molecules to the CNS...
Amyloid Oligomer Antibody—One Size Fits All?
Like good cholesterol and bad cholesterol, the Alzheimer's community has realized that there may also be good Aβ and bad Aβ...
No Pony in There: Bapi Fails Mild to Moderate ApoE4 Carriers
Pfizer conceded that results of the first of four Phase 3 trials of intravenous bapineuzumab failed to meet its co-primary endpoints in patients with mild to moderate AD...
Does ApoE4 Lower Brain Metabolism Independently of Aβ?
Chalk another one up for the “not-all-about-amyloid” camp...
Escort Service: P-Glycoprotein Ushers Aβ from Brain
Keeping brain amyloid-β (Aβ) levels in check means controlling both the means of production and the method of disposal...
ABCA1 Loss Lowers ApoE, Not Amyloid; New ApoE Immunology
A foursome of papers on ApoE deserves attention this week. Having plenty of ApoE is a prerequisite for...
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