Decision Date on Leqembi Traditional Approval Set for July
The U.S. Food and Drug Administration will convene an advisory committee to guide its decision, which will affect how widely available the treatment will be.
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The U.S. Food and Drug Administration will convene an advisory committee to guide its decision, which will affect how widely available the treatment will be.
Carriers of R145C were more likely to get AD, but only if they co-inherited a copy of ApoE4.
When growing among healthy human neurons, astrocytes that lack progranulin cause TDP-43 to aggregate and muck up neuronal gene splicing.
Shrinkage of distinct brain regions in the frontal and temporal lobes may unsuppress neural activity in the dorsal stream, a region involved in visual perception.
A protective variant promotes anti-inflammatory microglia, while a risk variant depletes them.
Across a three-decade span, there was no difference in amyloid pathology, but younger cohorts had healthier cerebrovasculature.
In mice, nixing ApoE4 from neurons squelched tau pathology, myelin loss, and neuronal death.
In mice, the neuronal transcription factor NPAS4 recruits DNA repair machinery to active promoters; without it, double-strand DNA breaks accumulate.
A single injection with CRISPR machinery suppressed mutant protein and improved gait and survival, suggesting the strategy deserves further exploration.
The fatty acid shields Syt11 from degradation. With more of it around, α-synuclein monomers cling to membranes.
Meaningfulness must account for the disease stage a patient is at, his or her priorities, and effects over time, researchers say.
Scientists turned iPSCs from people with ALS or Parkinson’s into motor neurons or dopaminergic neurons, respectively, then characterized them with a plethora of multi-omics.
Cognitively normal older adults with high levels of the biomarker slid quickly toward dementia.
Can joint analysis of gene expression, chromatin, and transcription factors help explain how transcription changes in Alzheimer’s disease?
In mice, oligomeric Aβ causes these macrophages to produce SPP1. Knocking out this pro-inflammatory cytokine quiets microglia and protects synapses.
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