PWAS x GWAS? Proteome Analysis Nets 10 New Alzheimer’s Genes
By comparing protein changes with GWAS data, scientists identified new links to AD. This method can unearth genes that otherwise fall short of genome-wide significance.
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Make Proteins, Save Memory: The Cellular Stress Response and Synapses
In mouse models of Aβ toxicity and amyloidosis, inhibiting the integrated stress response restored protein production, spared synapses, and brought back memory.
Striking Microgliosis in New APP Knock-in Mice
Plaques abound, cytokines spike, microglia swell with lipids and send out spermine SOS signals in Denali model. Mice will be shared, allowing unrestricted use.
In the United States, Racial Disparities in Dementia Risk Persist
Despite overall falling dementia rates in the U.S., black people remain more susceptible than whites.
Fatal Gift Wrap: Neurons Fall for Packaged Tau Oligomers
Neurons take up extracellular vesicles containing tau oligomers more readily than they do free tau. Some gift: This speeds the march of tauopathy through mouse brain.
Aβ Binds Glutamate Receptors. Only in Guys, Though.
In both mice and (wo)men, the sex difference comes down to an Aβ-glutamate receptor-prion protein troika.
Expression Analysis Uncovers Three Distinct Forms of Alzheimer’s
High amyloid burden and neuroinflammation, neuronal excitability, and tangles and oligodendrocyte loss distinguish the disease types.
Plasma P-Tau181 Predicts, Monitors Alzheimer’s Progression
The blood-based marker may be far more scalable and cost-effective for tracking the disease than PET imaging and CSF biomarkers.
Myeloid Metabolic Crisis May Trigger Cognitive Decline in Aging Brain
Aging macrophages and microglia poorly burn glucose and enter an inflammatory state. Revving their metabolism preserved synapses and memory in mice. What does prostaglandin have to do with it?
How Does COVID-19 Affect the Brain?
Some people with severe COVID-19 have neurovascular injury and elevated markers of neural damage in their blood and CSF. What’s going on in their brains?
Aducanumab Decision Delayed for Three Months
In response to an FDA request, the drug’s sponsor submitted new data analyses. The agency moved the action date to June 7.
Selective Vulnerability News: RORB Neurons Are First Victims of Tangles
By tracing the transcriptomes of neurons that wither early and late in the course of Alzheimer’s disease, researchers peg subpopulations of excitatory neurons in entorhinal cortex as selectively vulnerable to tau. Reactive astrocytes aid and abet.
Does Parkin Substrate Kick-Start Lewy Bodies?
Amyloids of AIMP2 found in Parkinson’s disease may seed α-synuclein aggregation.
Biomarkers of Errant Endosome Spotted in Cerebrospinal Fluid
In mice, forebrain neurons with hobbled retromers ooze fragments of tau and several BACE1 substrates into the CSF. Similar proteins are up in CSF from people with MCI and Alzheimer’s disease.
Huntingtin Repeats Cause—FTD, Caveolin Variants—ALS?
Breaking familiar gene-disease patterns, HTT trinucleotide expansions lead to huntingtin aggregates in prefrontal cortex. Noncoding caveolin 1 variants suppress its expression.
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