Hello Mitochondriomics: Tagging Method Identifies Different Subtypes
The organelles express unique sets of proteins depending on their environment. Astrocyte mitochondria process lipids better than those in neurons.
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Tiny Brain Structure Plays Big Role in Memory
New data strengthen the idea that a healthy locus coeruleus keeps memory sharp into old age.
Among AD Mutations, Only ApoE4 Seems to Hobble Microglia
In induced human microglia, the E4 allele profoundly affected their health and cellular responses, while familial Alzheimer’s mutations had little effect.
“Runner Plasma” Jogs Neurogenesis, Quells Neuroinflammation in Mice
Sedentary mice infused with the plasma of active ones had more newborn neurons in the brain and less neuroinflammation. Exercising upped plasma clusterin in mice and in humans.
Frontal Metabolic Patterns Mark Behavioral Subtype of AD
Hypometabolism in the frontal cortex and in the anterior default mode network distinguish the behavioral variant of AD from typical AD.
Adenosine Receptors Rev Up Immune Response, Memory Loss, in Tau Model
Overexpressing neuronal A2A receptors stoked C1q in microglia, damaging synapses and memory.
In Tauopathy, ApoE Destroys Neurons Via Microglia
Ablating the immune cells protected mouse models of frontotemporal dementia from the neurodegeneration caused by human ApoE4.
Right Turn: Aβ Fibril Structure from Alzheimer’s Brain Reveals Surprising Twist
The first ever cryo-EM structures of Aβ fibrils extracted from AD tissue look quite different than prior structures of fibrils generated in vitro. For starters, they are right-hand twisted, not left-hand.
ApoE4 and Tau in Alzheimer’s: Worse Than We Thought? Especially in Women
Imaging studies suggest that ApoE4 carriers may be more susceptible to the effects of tangles, particularly if they are women.
Mitochondrial Jetsam Spurs Neurodegeneration
Spewed by stressed microglia, fragments of the organelles provoke mitochondrial fission in other cells, causing astrogliosis and neuronal loss.
Do Immune Cells in the Meninges Help with … Memory?
Resident T cells in the membrane surrounding the healthy mouse brain influence both short-term memory and synaptic plasticity.
Introducing: iPSC Collection from Tauopathy Patients
The resource boasts 56 stem cell lines derived from tau mutation carriers, patients with sporadic disease, healthy controls, and engineered isogenic lines, including some that have their mutation corrected by CRISPR.
Can an ApoE Mutation Halt Alzheimer’s Disease?
The rare ApoE3 Christchurch variant prevented tau tangles, neurodegeneration, and cognitive decline in a woman’s brain for decades, despite massive amyloid buildup from a familial presenilin AD mutation.
Amyloid—It’s Not Whether, but for How Long You’ve Had It
A new study argues that the duration of a person’s amyloid positivity predicts whether they’ll develop tau accumulation and cognitive decline.
Already in Mid-30s, Poor Vascular Health Means Small Brain at 70
No link found with amyloid deposition.
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