Paper Alert: CryoEM Structures of α-Synuclein Published
In stark contrast to Aβ and tau fibrils, α-synuclein fibrils are asymmetric, comprising two different protofibrils.
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Low-Dose BACE Inhibitors Might Preserve Synaptic Function
In cell culture, slashing Aβ production by more than half harmed neuronal signaling, but a smaller cut maintained it.
At CTAD, Early Failures and Hints of Success, from Small Trials
A half-dozen lesser-known compounds in trials for Alzheimer’s disease posted results at the CTAD conference.
Boost or Block TREM2? Either Way, Therapy May Need Careful Timing
New research suggests the R47H variant protects neurons from neurodegeneration, raising questions about staging and direction of future TREM2-based therapy.
Paper Alert: Astrocytes Convert to Neurons (of the Dopaminergic Persuasion)
By suppressing a single gene, scientists triggered the transformation of astrocytes into neurons in the mouse substantia nigra, where the converts released dopamine and connected with the striatum.
Paper Alert: Two ApoE2s Provide “Exceptional” Protection Against AD
Compared with people who carry two copies of ApoE3 or ApoE4, ApoE2 homozygotes had an 87 and 99.6 percent lower risk for AD, respectively.
In Mice, Activating TREM2 Tempers Plaque Toxicity, not Load
Alector’s AL002c antibody mobilizes microglia, reduces neuronal dystrophy, and restores normal behavior—all in mice. The clinical version is in Phase 1.
Does RhoA Rein in Microglial Madness?
A mouse study claims that the small GTPase restrains pro-inflammatory responses in microglia. Aβ oligomers inhibit RhoA, promoting Aβ deposition and neurodegeneration.
Behold the First Human α-Synuclein CryoEM Fibril Structure
At the at Tau2020 conference, scientists show high-resolution cryoEM of α-synuclein. Two different types of fibril are composed of asymmetric protofibril units.
With IL-33, Neurons Tempt Microglia to Nibble At Synapses
Released from hippocampal neurons in response to experience, the cytokine prompted microglia to eat extracellular matrix around synapses. This facilitated growth of new spines, and sharpened memory.
217—The Best Phospho-Tau Marker for Alzheimer’s?
P-tau217 appears sooner than p-tau181 in the brain, and it distinguishes AD from controls and other dementias even more cleanly.
MRI and Machine Learning Depict Brain Aging in Health, Disease
From more than 45,000 MRI scans, a typical pattern of brain aging emerges. Brains “age” faster in people who have a neurological disorder.
11th International Conference on HHV-6 and HHV-7
Going Viral: Alzheimer’s Research at Herpes Conference Herpesvirus: Trigger for Many Brain Pathologies? In light of recent work implicating human herpesviruses in AD, virologists invited Alzheimer’s researchers to join them at the 11th International ...
New Tool Kit Helps Physicians Recognize and Manage Lewy Body Dementias
A U.K. research program developed guidelines for clinical practice. In preliminary studies, it boosted diagnosis and improved patient care.
International Lewy Body Dementia Conference
New Tool Kit Helps Physicians Recognize and Manage Lewy Body Dementias Consortia Assemble Worldwide to Take on Lewy Body Dementia Dementia with Lewy bodies is a devastating disorder, combining some of the worst features of Alzheimer’s and Parkinson’s, but ...
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