Cholesteryl Esters Hobble Proteasomes, Increase p-Tau
Reducing these esters with statins and cholesterol-hydroxylase-activating drugs lowers phospho-tau and Aβ in neurons. One such drug is approved to treat HIV AIDS.
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Is a Woman’s Brain More Susceptible to Tau Pathology?
Among cognitively normal people with amyloid plaques, women have more tau tangles in the entorhinal cortex than do men. Does this indicate susceptibility, or resilience?
Immune Cells Clog Capillaries in Mice, Disrupt Memory
In mouse models of Alzheimer’s, neutrophils stick to capillaries in the cerebral cortex, reducing blood flow. Keeping those cells moving or depleting them altogether improved memory.
Multi-Gene Score Predicts Cognitive Decline Independently of Brain Imaging
A score based on the combined burden of a person’s Alzheimer’s risk variants correlated with plaques, tangles, cognitive decline, and even non-AD pathology. Are polygenic hazard scores ready for direct-to-consumer marketing?
Does High Iron Push a Person With Pathology Into Dementia?
How the element relates to neurodegeneration remains unclear.
Deep Blue for Aβ Blood Test?
IBM researchers in Australia identify a combination of four proteins in plasma that predicts amyloid positivity in cerebrospinal fluid, and correlates with progression to AD.
Unequal: Some Tau Haplotypes Carry More Risk Than Others
Analysis of 19 H1 MAPT subhaplotypes ties five to progressive supranuclear palsy.
From Menarche to Menopause: Shorter Span Linked to Higher Risk of Dementia
Women who started menstruation after the age of 16, and/or entered menopause before 47, had higher rates of dementia later in life.
In Football Players With Possible CTE, Tau-PET Reveals Subtle Tau Deposition
Flortaucipir in former NFL players cropped up in regions known to be affected by chronic traumatic encephalopathy, but uptake was low compared with AD. Whether this reflects low tau deposition or poor tracer binding remain to be seen.
Results from Verubecestat APECS Trial Published
The Phase 3 trial ended early when prodromal AD patients on the BACE1 inhibitor declined faster than those on placebo.
Flash! Beep! Gamma Waves Stimulate Microglia, Memory
Exposing AD mice to multisensory gamma therapy induced 40-Hz waves in their brains, plus effects on amyloid, tau, microglia, blood vessels, and cognitive function.
In Pathology Cascade, Microglia Rev Up After Plaques but Before Tangles
Amyloid plaques in postmortem human cortex correlated with the proportion of microglia that were activated, not with microglial numbers. Tau pathology and cognitive decline come later.
Take With a Grain of Salt: Mitigating Aβ Pathology With Sodium Rutin
A flavonoid reportedly spices up oxidative phosphorylation in microglial mitochondria, revving up phagocytosis of amyloid plaques in mouse models. The small study needs independent replication.
More Evidence for Distinct TDP-43 Droplets
Liquid beads of TDP-43 form independently of stress granules and sequester proteins needed for nucleocytoplasmic transport.
Is Klotho’s Partner FGF23 a Cognition Protein?
Perturbations in the hormone correlate with memory problems. But does FGF23 act in the brain, or affect cognition indirectly via the kidneys?
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