Do Immune Cells in the Meninges Help with … Memory?
Resident T cells in the membrane surrounding the healthy mouse brain influence both short-term memory and synaptic plasticity.
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Amyloid—It’s Not Whether, but for How Long You’ve Had It
A new study argues that the duration of a person’s amyloid positivity predicts whether they’ll develop tau accumulation and cognitive decline.
On The Docket at AD/PD: The Many Crimes of ApoE4
Microglia cleanup, mitophagy, axonal plasticity, blood-brain barrier. A renewed focus on ApoE4 is revealing new ways in which this isoform renders the brain vulnerable to Alzheimer’s.
Keep Your Enthusiasm? Scientists Process Brutal Trial Data
“We are learning” was the tenor of debate about the latest round of setbacks for anti-amyloid trials in symptomatic Alzheimer’s disease at a recent conference in Lisbon.
Traumatic Tau: Filaments from CTE Share Distinct Structure
Atomic resolution structures of tau filaments from three people with CTE revealed a common strain of tau induced by chronic head injuries.
Mysterious RNA Circles Crop up in Alzheimer’s Brain
The circular transcripts correlate with AD pathology and dementia severity, suggesting potential roles in pathogenesis or as biomarkers.
New Antibody Binds to Mid-Region, and Aggregates, of Tau
X-ray crystallography yields high-resolution structure.
In Entorhinal Cortex, Histone “Acetylome” Bears Mark of Alzheimer’s Disease
In AD brain, scientists see a genome-wide histone acetylation pattern replete with peaks near familiar AD genes such as APP, presenilin, tau, complement receptor, and more.
TDP-43 Joins Cell-To-Cell Propagation Gang
Much like tau, Aβ, and α-synuclein, pathological TDP-43 spreads through the mouse brain, following the trail of neuronal connections and corrupting healthy protein along the way.
Autopsy Study Confirms Flortaucipir PET Lights Up Tau Pathology
Case study in early onset AD finds PET ligand tracks regional tau burden.
TDP-43: Separating Physiological Wheat from Pathological Chaff
A new technique helps researchers single out and characterize toxic aggregates of TDP-43 from human brain.
Local Flavor: At Protein Level, Too, Human Microglia Are Diverse
Multiplexed marker analysis in single cells from human brain corroborates expression data, identifies microglia subsets in human brain.
Another Reason to Catch Some Zzzs: Sleep Regulates Tau Release
Studies in mice and humans show that sleep suppresses extracellular tau and slows its spread.
In Alzheimer’s, Too Little REST Spurs Too Much Neurogenesis
Neural progenitor cells derived from people with sporadic AD are missing the transcriptional repressor REST in the nucleus. This lets neurogenesis run wild, exhausting a person’s stem cell pool.
Panel of Blood Markers Signals Amyloid in Brain
In cognitively normal people, a set of blood proteins may predict whether or not amyloid plaques have deposited in a person’s brain.
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