Autophagy, Inflammation, Degeneration: Parsing an Unholy Trinity
In a fly model of neurodegeneration, CDK5 slams autophagy, which leads to a runaway immune response that shoves aging neurons over the edge.
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New PET Tracer Selectively Lights Up Activated Microglia in Brain
The ligand binds the microglia-specific CSF1 receptor in animal and postmortem studies; human trials are forthcoming.
Tau, More than Aβ, Affects Sleep Early in Alzheimer’s
During deep sleep, people with AD pathology, particularly tau tangles, have less low-frequency slow-wave brain activity, which is important for memory consolidation.
Tregs Suppress Astrogliosis and Improve Recovery After Stroke
Regulatory T cells rush into the brain after a stroke, quelling astrocytosis and aiding neural recovery.
Take With a Grain of Salt: Mitigating Aβ Pathology With Sodium Rutin
A flavonoid reportedly spices up oxidative phosphorylation in microglial mitochondria, revving up phagocytosis of amyloid plaques in mouse models. The small study needs independent replication.
More Evidence for Distinct TDP-43 Droplets
Liquid beads of TDP-43 form independently of stress granules and sequester proteins needed for nucleocytoplasmic transport.
Is Klotho’s Partner FGF23 a Cognition Protein?
Perturbations in the hormone correlate with memory problems. But does FGF23 act in the brain, or affect cognition indirectly via the kidneys?
Neurogenesis Tapers In Older Brains, But Plummets in Alzheimer’s
Using rigorous tissue-processing techniques, researchers find thousands of newborn neurons in older human hippocampi, but a dearth in brains with AD pathology.
CD22 Suppresses Microglial Phagocytosis—A New Therapeutic Target?
Blocking the receptor clears toxic proteins and improves memory in old mice. The work proposes a new role in microglia for a well-known B-cell receptor.
Amyloid-PET Results Lead Some to Ponder Assisted Death in Future
In a research study, one-fifth of healthy people who learned they were at high risk for AD said they might consider physician-assisted death as a future option.
Bump in the Road or Disaster? BACE Inhibitors Worsen Cognition
The effect is small and stable, but consistent across several drugs. Researchers at CTAD debated whether it might be manageable by adjusting dosing.
Microglia Instigate ‘Chemofog’ by Squelching Myelination
Chemotherapy riles microglia, causing neurons to turn down expression of BDNF, a growth factor necessary for myelination. Restoring BDNF signaling on oligodendrocytes spared myelin and memory loss.
Human Microglia Make Themselves at Home in Mouse Brain
Analysis of a chimeric mouse shows that the cells express the same genes they do in the human brain, survey their environment, and respond to injuries and amyloid.
Gene Disruption Haunts Tau Mouse—Knock-Ins Look Promising
Much of the neuron loss in rTg4510 mice comes from accidental disruptions in mouse genes rather than expression of mutant tau. Pathology spreads quickly in human tau knock-ins.
Mitochondrial Jetsam Spurs Neurodegeneration
Spewed by stressed microglia, fragments of the organelles provoke mitochondrial fission in other cells, causing astrogliosis and neuronal loss.
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