Human Microglia Make Themselves at Home in Mouse Brain
Analysis of a chimeric mouse shows that the cells express the same genes they do in the human brain, survey their environment, and respond to injuries and amyloid.
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Gene Disruption Haunts Tau Mouse—Knock-Ins Look Promising
Much of the neuron loss in rTg4510 mice comes from accidental disruptions in mouse genes rather than expression of mutant tau. Pathology spreads quickly in human tau knock-ins.
On The Docket at AD/PD: The Many Crimes of ApoE4
Microglia cleanup, mitophagy, axonal plasticity, blood-brain barrier. A renewed focus on ApoE4 is revealing new ways in which this isoform renders the brain vulnerable to Alzheimer’s.
Keep Your Enthusiasm? Scientists Process Brutal Trial Data
“We are learning” was the tenor of debate about the latest round of setbacks for anti-amyloid trials in symptomatic Alzheimer’s disease at a recent conference in Lisbon.
Traumatic Tau: Filaments from CTE Share Distinct Structure
Atomic resolution structures of tau filaments from three people with CTE revealed a common strain of tau induced by chronic head injuries.
Are Tauopathies Caused by Neuronal and Glial Senescence?
Removing senescent cells from mouse brain ameliorates the effects of mutant human tau.
Does APP Promote Synapse Loss, Aβ Production Through Wnt Signaling?
A Wnt pathway inhibitor rescued dendritic spines in cultured neurons and cleared plaques in an AD mouse model.
New Antibody Binds to Mid-Region, and Aggregates, of Tau
X-ray crystallography yields high-resolution structure.
In Entorhinal Cortex, Histone “Acetylome” Bears Mark of Alzheimer’s Disease
In AD brain, scientists see a genome-wide histone acetylation pattern replete with peaks near familiar AD genes such as APP, presenilin, tau, complement receptor, and more.
TDP-43 Joins Cell-To-Cell Propagation Gang
Much like tau, Aβ, and α-synuclein, pathological TDP-43 spreads through the mouse brain, following the trail of neuronal connections and corrupting healthy protein along the way.
Autopsy Study Confirms Flortaucipir PET Lights Up Tau Pathology
Case study in early onset AD finds PET ligand tracks regional tau burden.
TDP-43: Separating Physiological Wheat from Pathological Chaff
A new technique helps researchers single out and characterize toxic aggregates of TDP-43 from human brain.
Local Flavor: At Protein Level, Too, Human Microglia Are Diverse
Multiplexed marker analysis in single cells from human brain corroborates expression data, identifies microglia subsets in human brain.
Another Reason to Catch Some Zzzs: Sleep Regulates Tau Release
Studies in mice and humans show that sleep suppresses extracellular tau and slows its spread.
In Alzheimer’s, Too Little REST Spurs Too Much Neurogenesis
Neural progenitor cells derived from people with sporadic AD are missing the transcriptional repressor REST in the nucleus. This lets neurogenesis run wild, exhausting a person’s stem cell pool.
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