Plasticity Hums With Protein Synthesis on Both Sides of Synapse
Long recognized in dendrites, scientists now report that substantial synaptic proteome remodeling happens on the axonal side, too.
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Gamma Waves Synchronized by Light: Good for Synapses, Memory?
More mouse data add to the argument that a flashing light sequence could potentially fight cognitive decline.
WHO Weighs in With Guidelines for Preventing Dementia
The global agency’s report recommends physical activity, a healthy diet, stopping alcohol abuse and smoking, and managing one’s weight, blood pressure, and diabetes.
Keep Your Enthusiasm? Scientists Process Brutal Trial Data
“We are learning” was the tenor of debate about the latest round of setbacks for anti-amyloid trials in symptomatic Alzheimer’s disease at a recent conference in Lisbon.
Forget Fibrils: Lewy Pathology Is More Lipid Than Protein
An electron microscopy study reveals a jumbled mess of membrane chunks and malfunctioning organelles, bound together by phosphorylated or truncated α-synuclein.
Do Immune Cells Promote the Spread of α-Synuclein Pathology?
At AD/PD 2019, scientists implicated both peripheral and central innate immunity in promoting propagation.
Antibodies Against Microglial Receptors TREM2 and CD33 Head to Trials
As data increasingly blame the microglia response as a driving force in Alzheimer’s disease, researchers are investigating whether tempering these cells will aid cognition.
Drug Reported to Help Alzheimer’s Patients Sleep Better
An FDA-approved insomnia drug lengthened total sleep time in patients with mild to moderate Alzheimer’s, suggesting it might be able to lessen a troublesome symptom of the disease.
Longitudinal Tau-PET Links Aβ to Subsequent Rise in Cortical Tau
In the largest study yet to track tau via repeated PET scans, researchers found that tau pathology increased over baseline only in people with Aβ deposition. The more tau a person had at baseline, the more tau increased later on, and the more they slipped on cognitive tests.
Amyloid-PET Results Lead Some to Ponder Assisted Death in Future
In a research study, one-fifth of healthy people who learned they were at high risk for AD said they might consider physician-assisted death as a future option.
Off-Balance Endocytosis Lays Groundwork for Disease
By aging cultured neurons and manipulating them to stimulate endocytosis or interfere with vesicle release, researchers can bring about characteristics of Alzheimer’s—without adding APP or Aβ.
Plasma NfL Goes the Distance in Alzheimer’s
In ADNI, blood marker exposes ongoing neurodegeneration across disease stages.
Introducing LATE—A Common TDP-43 Proteinopathy that Strikes After 80
Scientists propose that LATE is a neurodegenerative disease marked by TDP-43 pathology in limbic regions, and memory loss. After death, it can be seen alone or with other pathology.
On The Docket at AD/PD: The Many Crimes of ApoE4
Microglia cleanup, mitophagy, axonal plasticity, blood-brain barrier. A renewed focus on ApoE4 is revealing new ways in which this isoform renders the brain vulnerable to Alzheimer’s.
ARIAS: Zooming in On Eye-based Biomarkers for Alzheimer’s
Scientists know that the retina changes in people with preclinical AD; alas, there is neither consensus nor convergence in the field of retinal imaging. An upcoming initiative aims to determine which measures are most robust.
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