Flortaucipir Imaging Distinguishes Alzheimer’s From Other Disorders
A large multicenter study confirms the tau PET ligand identifies AD at the dementia stage, but not so well at prodromal stages.
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Panel of Blood Markers Signals Amyloid in Brain
In cognitively normal people, a set of blood proteins may predict whether or not amyloid plaques have deposited in a person’s brain.
Viral Vectors Trigger Robust Tauopathy in Brain Slices
The approach provides an in vitro system that more closely resembles the brain milieu than do cell cultures, and can be used to model other proteinopathies as well.
Nixing Neuron Receptor Improves Recovery from Stroke, Trauma
Knocking down or blocking the CCR5 receptor with an HIV drug improved motor symptoms and learning and memory in a mouse model of stroke. Recently, researchers in China knocked out this gene in babies using CRISPR.
Alzheimer’s Association Report Argues for Cognitive Screening
Only 16 percent of seniors report being assessed for cognition during yearly checkups. Eighty-two percent think it should be routine.
Too Little, Too Late? Blood Pressure and Cholesterol Meds Don’t Slow Cognitive Decline in 70s
In people at intermediate risk for cardiovascular disease, the meds had no effect on cognitive decline over six years.
In New Study, Diet During Midlife Not Linked to Dementia
Among British civil servants, the quality of their diet did not correlate with their risk of developing dementia cognitive decline over 25 years.
Compound Stimulates Lysosome, Clears Tau in Human Cells and Mice
A prospective progeria drug revs up cellular autophagy and clears tau in neurons derived from patients with frontotemporal dementia. In mouse models, the drug rescues abnormal behavior.
Mixed Messages: mRNA Splicing Errors May Promote Alzheimer’s
A large-scale expression study finds mis-splicing of a specific set of genes in AD brain that includes several known risk genes.
Noncoding RNAs Evince World of Gene Regulation in Dopaminergic Neurons
Using TNEs—snippets of RNA transcribed from noncoding regions—as a gauge of enhancer activity, researchers tied Parkinson’s risk variants to gene regulation.
Plaques Age Glial Precursors, Stoking Inflammation
Senolytic drugs kill these cells, temper Aβ, and improve cognition in transgenic mice.
Life Without Microglia: Rare Cases of CSF-1R Mutations Paint a Grim Picture
In people carrying two mutated copies of the trophic receptor, important brain structures, such as the corpus callosum, never developed.
Could CD33 Be the Microglial Target for Stimulating Phagocytosis?
Inhibiting the receptor activates microglia to mop up debris, making CD33 an attractive therapeutic target.
Spitting, Sniffing: Is This How We Will Dx Parkinson’s?
Scientists are probing saliva and skin secretions for telltale signs of Parkinson’s disease. Their prize? A diagnostic test at the pre-motor stage.
Longitudinal Tau-PET Links Aβ to Subsequent Rise in Cortical Tau
In the largest study yet to track tau via repeated PET scans, researchers found that tau pathology increased over baseline only in people with Aβ deposition. The more tau a person had at baseline, the more tau increased later on, and the more they slipped on cognitive tests.
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