In DIAN, participants who are more physically active may also have slower disease progression.
Serial data establishes different trajectories for CSF t-tau and p-tau.
A large multicenter study confirms the tau PET ligand identifies AD at the dementia stage, but not so well at prodromal stages.
Ablating BACE1 in adult mice spares them from most problems found in germline knockouts. However, axons extending from newborn hippocampal neurons still lose their way.
By promoting the exocytosis of cellular debris, the kinase may facilitate spread of α-synuclein aggregates.