High-Resolution Map of Hippocampus Reveals Multiple Subnetworks
The most detailed look yet at hippocampal wiring may guide future functional studies and disease research.
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ALS on a Chip—A Model for Screening Therapeutics?
Neuromuscular junctions between human stem cell-derived motor neurons and skeletal muscle fibers faltered when cells came from an ALS patient.
Crystal Structure of Aβ and Proposed Receptor Solved
A small molecule that protects neurons fends off a short region of Aβ from a specific pocket on the LilrB2 receptor.
Mixed Messages: mRNA Splicing Errors May Promote Alzheimer’s
A large-scale expression study finds mis-splicing of a specific set of genes in AD brain that includes several known risk genes.
Intelligence Matters More for Brain Reserve, but Education Helps
Longitudinal and genetic studies reveal that intelligence underlies cognitive reserve.
Sans Synuclein Tetramers, Mice Mimic Parkinson’s Disease
Mutations that destabilize α-synuclein tetramers leave young mice with severe and progressive motor problems resembling those of PD.
Noncoding RNAs Evince World of Gene Regulation in Dopaminergic Neurons
Using TNEs—snippets of RNA transcribed from noncoding regions—as a gauge of enhancer activity, researchers tied Parkinson’s risk variants to gene regulation.
Dipeptide Repeat Proteins Trigger TDP-43 Pathology, Faulty Nuclear Import
In a fly model, C9ORF72 pathology pulls TDP-43 from the nucleus, which leads to disrupted nuclear import and neurodegeneration.
Does APP Promote Synapse Loss, Aβ Production Through Wnt Signaling?
A Wnt pathway inhibitor rescued dendritic spines in cultured neurons and cleared plaques in an AD mouse model.
ALS Gene Tied to Psychiatric and Neurodevelopmental Disease
Families of ALS and FTD patients with C9ORF72 expansions have more mental illness, suggesting the gene affects brain function throughout life.
In Mice, Caspase-1 Inhibitor Quells Inflammation, Aβ, Memory Loss
VX-765 could be a therapeutic candidate for Alzheimer’s disease.
Are Tauopathies Caused by Neuronal and Glial Senescence?
Removing senescent cells from mouse brain ameliorates the effects of mutant human tau.
Nilvadipine Fails to Slow Cognitive Decline in AD Patients
Believed to be an amyloid-lowering agent, the blood pressure drug did not help people at the dementia stage of disease.
$2.34 Billion Alzheimer’s Budget Signed Into Law
The bill tops last year’s budget for the disease by $425 million.
RNA-Binding Protein Linked to Ataxin-2 toxicity
Staufen1 may deplete certain mRNAs, precipitating the death of Purkinje and other neurons.
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