26 Oct 2018
Despite having a higher incidence of Alzheimer’s or a related dementia, relatively few black people participate in research studies or drug trials. How to achieve full representation?
26 Oct 2018
In AD brain, scientists see a genome-wide histone acetylation pattern replete with peaks near familiar AD genes such as APP, presenilin, tau, complement receptor, and more.
23 Oct 2018
Clusters of neurons harboring somatic mutations in 56 genes linked to neurodegenerative diseases may be commonplace in the human brain.
22 Oct 2018
X-ray crystallography yields high-resolution structure.
20 Oct 2018
An antibody that binds fibrin blocks neuro-inflammatory signaling while allowing normal clotting.
19 Oct 2018
Analysis of MRI brain volume data identifies multiple AD and FTD/ALS disease subtypes with distinct patterns of degeneration over time.
19 Oct 2018
The most detailed look yet at hippocampal wiring may guide future functional studies and disease research.
18 Oct 2018
Neuromuscular junctions between human stem cell-derived motor neurons and skeletal muscle fibers faltered when cells came from an ALS patient.
16 Oct 2018
A small molecule that protects neurons fends off a short region of Aβ from a specific pocket on the LilrB2 receptor.
13 Oct 2018
A large-scale expression study finds mis-splicing of a specific set of genes in AD brain that includes several known risk genes.
12 Oct 2018
Longitudinal and genetic studies reveal that intelligence underlies cognitive reserve.
12 Oct 2018
Mutations that destabilize α-synuclein tetramers leave young mice with severe and progressive motor problems resembling those of PD.
08 Oct 2018
Using TNEs—snippets of RNA transcribed from noncoding regions—as a gauge of enhancer activity, researchers tied Parkinson’s risk variants to gene regulation.
05 Oct 2018
In a fly model, C9ORF72 pathology pulls TDP-43 from the nucleus, which leads to disrupted nuclear import and neurodegeneration.
05 Oct 2018
A Wnt pathway inhibitor rescued dendritic spines in cultured neurons and cleared plaques in an AD mouse model.