ApoE Binds Complement Protein, Keeps Inflammatory Cascade in Check
Binding occurs around lipid deposits in the choroid plexus, near Aβ deposits, and also in atherosclerotic plaques in blood vessels.
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In Pathology Cascade, Microglia Rev Up After Plaques but Before Tangles
Amyloid plaques in postmortem human cortex correlated with the proportion of microglia that were activated, not with microglial numbers. Tau pathology and cognitive decline come later.
Blood Test Granted Breakthrough Status, To Be Tested in Trial
The FDA has prioritized review of C2N’s blood test for amyloid-β. A pivotal clinical trial will correlate the test with amyloid PET scans.
Roche Pulls Plug on Two Phase 3 Trials of Crenezumab
An interim analysis predicted the antibody would not slow Alzheimer’s progression; a crenezumab trial in autosomal-dominant AD is continuing.
SPRINT MIND Data Published, Follow-Up Extended
Reducing systolic blood pressure staves off cognitive decline, but what about dementia?
An Antimicrobial Approach to Treating Alzheimer’s?
A periodontal pathogen found in human brains triggers AD pathology in mice. Will an antibiotic stave off dementia?
Dementia: Frailty Hastens It, Physical Activity Wards It Off
Frail people may be more likely to have Aβ plaques and neurofibrillary tangles; when they do, they are more likely to have dementia. Physical activity correlated with better global cognition, regardless of brain pathology.
Another Reason to Catch Some Zzzs: Sleep Regulates Tau Release
Studies in mice and humans show that sleep suppresses extracellular tau and slows its spread.
Rocking Improves Sleep and Memory in Adults
Ever wonder why it’s so easy to nod off in a hammock? Turns out swaying back and forth improves sleep and even enhances memory in people.
BACE and γ-Secretase Form Mega-Complex that Processes APP
Are high-molecular-weight, multi-protease complexes cellular Aβ factories?
Neurofilament in Blood Foretells Early Onset Alzheimer’s
In familial Alzheimer’s disease, rise in NfL in the blood precedes disease onset by 16 years.
Invasion of the Microtubules: Mutant Tau Deforms Neuronal Nuclei
In neurons derived from FTD patients, microtubules distort the nucleus, warping its normally rounded membrane and disrupting communication with the cytoplasm.
Deadline to Weigh In on New Biomarker Guidance Approaches
Stakeholders have until February 11 to comment on draft FDA guidance for biomarker qualification.
Microtubule Regulator Connects TDP-43 to Axonal Dysfunction
Two independent studies find that loss of nuclear TDP-43 leads to mis-splicing of stathmin 2, an essential protein for axon growth and repair.
Absent Aβ, Blood-Brain Barrier Breakdown Predicts Cognitive Impairment
A leaky blood-brain barrier in the hippocampus correlated with cognitive impairment, independently of other vascular risk factors or Alzheimer’s pathology.
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