Plasma NfL Goes the Distance in Alzheimer’s
In ADNI, blood marker exposes ongoing neurodegeneration across disease stages.
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Plasticity Hums With Protein Synthesis on Both Sides of Synapse
Long recognized in dendrites, scientists now report that substantial synaptic proteome remodeling happens on the axonal side, too.
The Mutation You Want: It Protects the Brain, Extends Life
A PLCG2 variant that reduces a person’s risk of Alzheimer’s, frontotemporal dementia, and dementia with Lewy bodies also appears to extend longevity.
Flash! Beep! Gamma Waves Stimulate Microglia, Memory
Exposing AD mice to multisensory gamma therapy induced 40-Hz waves in their brains, plus effects on amyloid, tau, microglia, blood vessels, and cognitive function.
Parsing Local and Distal Aβ Shows Links to Metabolism, Cognition
Aβ deposits make distal neurons vulnerable to insults, including from local Aβ, says imaging study. The combination hastens cognitive decline.
Wild Mice Inject Genetic Diversity into Models of Alzheimer’s Disease
New strains have amyloid, neurodegeneration, and neuroinflammation, all against a background of natural genetic variation.
Brainstem GABAergic Inputs to Hippocampus Control Memory Formation
The locus incertus fine-tunes hippocampus neural activity to control memory formation in stressful situations. Could a new understanding of these circuits shed light on memory loss in Alzheimer’s?
In Pathology Cascade, Microglia Rev Up After Plaques but Before Tangles
Amyloid plaques in postmortem human cortex correlated with the proportion of microglia that were activated, not with microglial numbers. Tau pathology and cognitive decline come later.
Serial PET Nails It: Preclinical AD Means Amyloid, Tau, then Cognitive Decline
Serial amyloid and tau scans in cognitively healthy people indicate that the speed at which a person’s tau accumulates best predicts his or her future cognitive decline.
Forget Fibrils: Lewy Pathology Is More Lipid Than Protein
An electron microscopy study reveals a jumbled mess of membrane chunks and malfunctioning organelles, bound together by phosphorylated or truncated α-synuclein.
Jumping Genes Rampant in Tau Flies
By loosening their chromatin straitjackets, and reining in their RNA watchdogs, tau unleashes transposable elements into the genome.
'Organ on a Chip' Models the Ins and Outs of the Blood-Brain Barrier
The microfluidic device could test the vascular contributions to neurodegenerative disease and bioavailability of drugs for the brain.
Surprise: HDAC Goes Down, Not Up, in Alzheimer’s Disease
A new PET tracer belies previous results from animal models and postmortem studies. Caveat emptor for trials of HDAC inhibitors?
ApoE: Common Microglial Culprit in Aging, Alzheimer’s, and Tauopathy?
Translatome profiling suggests ApoE drives a microglial gene-expression signature found in aging, Aβ amyloidosis, and tauopathy.
Tau Stymies Transport Through Neuron’s Nucleus
By yanking a nuclear protein out of its pore, phosphorylated tau makes nuclei leaky, disrupting the strictly controlled passage of proteins and setting tau up for aggregation.
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