Biogen/Eisai Halt Phase 3 Aducanumab Trials
Futility analysis predicts failure to reach primary endpoint.
ALL NEWS
285 RESULTS
Sort By:
- Most Recent
- Most Commented
BAN2401 Removes Brain Amyloid, Possibly Slows Cognitive Decline
Researchers consider the data encouraging, though questions linger about the cognition results. Did regulators mess up the randomization of this trial?
When Host Proteins Coat Virus, Amyloid Fibrils Form
Viral surfaces attract proteins from the extracellular environment of the person they infect. This corona of host proteins makes the virus more or less infective—and promotes amyloid fibrils.
CryoEM γ-Secretase Structures Nail APP, Notch Binding
First look at substrate interactions reveals similarities but some surprises.
Closing the Book on NSAIDs for Alzheimer’s Prevention
The latest effort to determine if a non-steroidal anti-inflammatory drug protects against Alzheimer’s posted negative results. Time to abandon the approach?
Lymphatic Brain Drain Withers in Aging, Worsens Disease
Aging lymphatic vessels in the meninges hinder waste clearance from the brain and exacerbate Aβ build-up.
ApoE Binds Complement Protein, Keeps Inflammatory Cascade in Check
Binding occurs around lipid deposits in the choroid plexus, near Aβ deposits, and also in atherosclerotic plaques in blood vessels.
Confirmed: Human Pituitary Extract Linked to Amyloidosis Contains Aβ Seeds
The material, previously used to treat children with growth deficiencies, triggered amyloid deposition in transgenic mice.
BACE and γ-Secretase Form Mega-Complex that Processes APP
Are high-molecular-weight, multi-protease complexes cellular Aβ factories?
Introducing LATE—A Common TDP-43 Proteinopathy that Strikes After 80
Scientists propose that LATE is a neurodegenerative disease marked by TDP-43 pathology in limbic regions, and memory loss. After death, it can be seen alone or with other pathology.
Dementia Researchers Commend FDA Crackdown on Supplement Hype
When the agency sent warning letters to 17 companies that falsely advertised cures and preventions for AD, most took down exaggerated claims. But can regulations stay ahead of the market?
Dipeptide Repeat Proteins Trigger TDP-43 Pathology, Faulty Nuclear Import
In a fly model, C9ORF72 pathology pulls TDP-43 from the nucleus, which leads to disrupted nuclear import and neurodegeneration.
Sans Synuclein Tetramers, Mice Mimic Parkinson’s Disease
Mutations that destabilize α-synuclein tetramers leave young mice with severe and progressive motor problems resembling those of PD.
Nilvadipine Fails to Slow Cognitive Decline in AD Patients
Believed to be an amyloid-lowering agent, the blood pressure drug did not help people at the dementia stage of disease.
Could Rogue APP Variants Invade Genome of Individual Neurons?
In a new take on mosaicism and Alzheimer’s, scientists claim that APP mRNAs convert into DNA and reinsert into the genome. Full of mutations, these “genomic cDNAs” crop up in aging and sporadic AD.
Current Filters
- Date Range : Jul 2018 to Jul 2019 x