Variants in the gene cluster MS4A associate with levels of soluble TREM2 in human cerebrospinal fluid. MS4A encodes transmembrane receptors implicated in lipid sensing.
Microfluidic tri-culture of neurons, astrocytes, and microglia models how glia impose deadly neuroinflammation on top of amyloid and tau pathology.
The proinflammatory molecule binds to Aβ oligomers and fibrils and slows nucleation in vitro, hinting it could have beneficial effects in the early stages of AD.
Herpes viruses that are commonly found in human brain promote rapid Aβ fibrillization and deposition in AD model systems.
Get up close and personal with the GABAA receptor, a key mediator of inhibitory signaling in the brain and a drug target in a wide range of disorders, including Alzheimer’s.
Chronic inhibition of protein synthesis, and slowing the dispersal of stress granules, contribute to neurodegeneration in C9ORF72 ALS/FTD.
In healthy neurons, small vesicles at the presynapse and larger ones in neurites harbor Aβ42, according to super-resolution microscopy.
Males are inflammatory, females are neuroprotective: Profiling of microglia from adult mice suggests sex-specific phenotypes, likely set at birth.
Roche and Prothena publish Phase 1b results for their antibody PRX002/RG7935.
Big data analyses correlate viral load with clinical, molecular, and pathological features of AD. Time to consider the pathogen hypothesis anew?
A large epidemiological study better defines the risk from hypertension. This may sharpen recommendations for prevention.