Do Earliest Cognitive Deficits in Alzheimer's Appear in the Entorhinal Cortex?
Older adults with amyloid in their brains develop abnormal activity in the entorhinal cortex even while memory and hippocampal function remain unaffected.
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Alzheimer’s Accountability Act Puts Price Tag on NAPA Goals
A new bill asks Congress to ramp up Alzheimer’s funding by breaking down the cost to meet each of the milestones in the national plan. It appropriates no funds.
European Parliament Passes Law to Open Trial Data
A new bill will centralize the approval process for multinational trials and mandate the publication of trial results—good or bad.
Another Partner for LRRK2: Will This Relationship Endure?
If new results hold up, enhanced phosphorylation of a ribosomal protein may explain the toxicity of mutations that cause Parkinson's.
Microglial Magic: Drug Wipes Them Out, New Set Appears
A small molecule inhibitor kills all microglia in the brain, but the cells rapidly repopulate from a previously unidentified progenitor cell.
Falsifications Cast Shadow Over Stem Cell Field
Allegations of scientist misconduct led to the retraction of one high-profile stem cell paper and put two others in doubt.
Are Synuclein Seeds Non-Starters?
A new study charges that, contrary to previous studies, seeding the mouse brain with aggregated α-synuclein does not trigger a toxic spread of PD-like inclusions in wild-type mice.
C9ORF72 Repeats Expand into New Disorders—Cause, or Coincidence?
Nucleotide repeat expansions in the C9ORF72 gene occur in amyotrophic lateral sclerosis and frontotemporal dementia. Now researchers find the same repeats in patients with two other neurological disorders.
Does Dendritic Tau Promote Plasticity?
New research suggests that dendritic tau may participate in synaptic plasticity, and that Aβ disrupts this function.
Muscle-Boosting Therapy Fails in Phase 2 Trial for ALS
Tirasemtiv, a drug thought to make muscles more sensitive to signals from motor neurons, failed to improve muscle function in people with amyotrophic lateral sclerosis.
Does PET Tracer Reveal Severity of Parkinson's?
Scientists claim that AV-133, an imaging agent that visualizes dopaminergic neurons, can gauge progression of Parkinson’s disease.
18 Years After Dolly, First Adult Human Cells Cloned
Scientists generate human embryonic stem cell lines from adult donor cells, building on earlier studies that showed this was possible with fetal cells.
Mesulam Awarded Potamkin Prize
Marek-Marsel Mesulam received the prestigious award for his research on primary progressive aphasia, a language disorder that can affect people with Alzheimer’s or frontotemporal dementia.
It’s Not All About You, Neurons. Glia, Blood, Arteries Shine at Symposium
Baby Boomers, keep your blood pressure down. Research is beginning to explain how even mild hypertension, a mid-life risk factor for late-life dementia, might be damaging the neurovascular unit.
2014 Zilkha Symposium on Alzheimer’s Disease and Related Disorders
It’s Not All About You, Neurons. Glia, Blood, Arteries Shine at Symposium Fluid Markers and Imaging Back Idea of Breached Blood-Brain Barrier In Revival of Parabiosis, Young Blood Rejuvenates Aging Microglia, Cognition Glymphatic Flow, Sleep, microRNA Are
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