Chaperone “Saves” Tau, Turning it into Toxic Oligomers
As heat shock protein and co-chaperone team up to shield tau from degradation, they create toxic oligomers.
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Glutamate Receptor Links Aβ-Prion Complex with Fyn, Synaptic Damage
New research connects extracellular Aβ to intracellular kinases that mediate its toxicity.
In Small Study, Brain Training Benefits Healthy Seniors
Older people improved memory and attention after playing a challenging video game, supporting the idea that multitasking could have benefits for cognition.
Fornix First—Atrophy Foreshadows Decline in Normal Aging?
New imaging data suggests degeneration of the fornix could help identify seniors on the verge of cognitive decline.
Non-Motor Symptoms Are an Early Sign of Parkinson's
A new study supports the idea that non-motor symptoms of Parkinson's disease may aid earlier diagnosis.
Does Aβ Come In Strains? Glimpse Into Human Brain Suggests Yes
Amyloid fibrils seeded by Alzheimer’s brain extracts indicate that Aβ forms specific strains in different individuals.
Alzheimer's Association International Conference 2013
Cerebrospinal Fluid Tau Climbs in Aβ Mouse Models Coverage Denial For Amyloid Scans Riles Alzheimer’s Community Pooled GWAS Reveals New Alzheimer’s Genes and Pathways Are Subtle Memory Concerns a Sign of Future Dementia? Clinical Trials Roundup: Four Hits
International Conference on Alzheimer's & Parkinson's Diseases 2013
Tau, α-Synuclein Spread: Crazy Stuff—How Might It Work? Like Star Born of Supernova, Plaque Born of Exploded Neuron? Can Dousing PyroGlu-Aβ Treat Alzheimer’s Disease? Field Ramps Up "Mini" Mouse MRI LRRK Watchers’ Eyes Turn to Inflammation, Auto
Human Amyloid Imaging 2013
Solanezumab Selected for Alzheimer’s A4 Prevention Trial HAI—Spotlight on Tau Tracers at Human Amyloid Imaging Meeting HAI—Amyloid Imaging in the Clinic: New Guidelines and Data HAI—Sharper Curves: Revamping a Biomarker Staging Model HAI—Standardizing Amy
A New Genetic Risk Factor for Early Onset Parkinson's
A deletion in chromosome 22 points to new genetic risk factors for Parkinson's disease.
Paper Alert: FUS a Fixer of Damaged DNA
FUS, a protein tied to neurodegeneration, normally mends DNA breaks, according to a paper in Nature Neuroscience.
Cellular Pruning Shears Reshape Connections in Adults
It's not just for neurodevelopment anymore. Death receptor 6—known for pruning axons—also trims unused connections in adulthood, hinting at a function in Alzheimer's.
Paper Alert: Preclinical Alzheimer’s Stages Predict Progression
Proposed preclinical stages for Alzheimer’s disease predict well who is most likely to progress to Alzheimer’s dementia.
Self-Derived Stem Cells Fly Under Monkey’s Immune Radar
What’s better for future treatment of Parkinson’s: patient-derived or banked iPSCs? In comparison, patient’s own come out on top.
Lou Gehrig’s RNA Interference Success in Mice, Monkeys
A new RNA interference therapy for amyotrophic lateral sclerosis has some success in mice and monkeys.
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