The covalent modification of proteins by phosphorylation of specific amino acids has evolved as a powerful and rapid way for cells to respond to a multitude of internal and external stimuli...
A meta-analysis of clinical trials indicates that cholinesterase inhibitors do more than boost cognitive test scores in Alzheimer's patients. As reported in yesterday’s Journal of the American Medical Association...
Early last month, 118 scientists braved a snowstorm on the Eastern seaboard to gather at Cold Spring Harbor Laboratory on Long Island, New York, for a conference on therapeutic opportunities in neurodegenerative diseases...
<strong>Raj Kalaria</strong> and <strong>Francine Gervais</strong> organized the Second International Conference on cerebral amyloid angiopathy (CAA), held December 4 to 6 in Newcastle upon Tyne, England...
In conflict with a number of recent studies, six-year data from the Rotterdam study of aging failed to show a link between dietary fat and risk of dementia. The results are reported in today’s Neurology...
Over 100 point mutations in the Cu/Zn superoxide dismutase (SOD) gene have been linked to the neurodegenerative disease amyotrophic lateral sclerosis (ALS). Exactly why these mutations cause ALS is unclear, but...
A new MAO-B inhibitor, rasagiline, proved safe and about as effective as the existing drug, selegiline, in ameliorating symptoms of early Parkinson's. What about its use in Alzheimer's with Parkinsonism?
Dendritic spines—tiny protrusions that mediate synaptic contacts between neurons—are present in vast numbers in the mammalian brain (up to ten thousand per neuron)...
In Alzheimer's, as in many other neurodegenerative diseases, neurons often meet their demise after apoptotic, or programmed cell death pathways have been activated...
Researchers from the biotechnology company SUGEN (a subsidiary of Pharmacia Corporation) and the Salk Institute in La Jolla, California, report that they have mapped all 518 protein kinases in the human genome...