A BOLD New Look at Neuronal MRI
Functional MRI (fMRI) is a powerful technique for measuring subtle magnetic resonance changes in active neurons, but it does have limitations. One commonly used fMRI method called BOLD...
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American Neurological Association: 2002 Annual Meeting
American Neurological Association Annual Meeting: Biomarkers and Mitochondrial Therapy American Neurological Association: 2002 Annual Meeting
American Neurological Association Annual Meeting: Biomarkers and Mitochondrial Therapy
Alzforum received several belated comments on some interesting studies presented at the American Neurological Association's annual meeting in New York City last fall. We thus present summaries of these studies...
New Insights and Strategies for Treating PolyQ Disorders
A flurry of recent papers is shedding new light on the role of proteins containing expanded polyglutamine tracts (polyQ) and their molecular partners, bringing researchers a small step closer toward understanding...
Pertussis Toxin Stokes Autoimmune Reaction in Aβ-Vaccinated Mice
In this month’s Brain, researchers at the Universities of Milan and Genoa, Italy, report that immunizing C57/Bl6 mice with Aβ42 generated an inflammatory response similar to an autoimmune disease in the brains of these mice...
Plaque Clearance, Antibody Isotype Are Key for Passive Aβ Immunization
Plaque clearance is a better correlate of neural protection via passive amyloid immunization than soluble amyloid-beta (Aβ) clearance, and this protection is based on Fc receptor-mediated Aβ phagocytosis...
Aβ's Shadowy Sibling—What Becomes of the Intracellular Domain?
In the January 31 online PNAS, Meir Scheinfeld, Shuji Matsuda, and Luciano D'Adamio of the Albert Einstein College of Medicine in Bronx, New York, show how the carboxyl terminus of AβPP could play a significant role in gene transcription...
Nathan Kline Institute in Peril
Faced with a multibillion dollar deficit, New York State’s Governor George Pataki last week proposed a budget plan that would merge the Nathan Kline Institute for Psychiatric Research in Orangeburg with the New York State Psychiatric Institute in Manhattan...
NSAIDs and Derivatives Keep Transthyretin in Its Place
Transthyretin, like Aβ, is capable of forming amyloid fibrils, and can lead to systemic amyloidosis in families who have inherited particularly fibrillogenic forms of the protein...
From Protein Trafficking to Episodic Memory: Tracing BDNF Genotypes
An ambitious attempt to link cognitive tests, functional brain imaging, and cell biological assays implicates a polymorphism in brain-derived neurotrophic factor (BDNF) as the source for highly specific memory deficits...
γ-Secretase Cuts Not Just Notch, but Ligands Delta and Jagged, Too
A report in the January 24 online Journal of Biological Chemistry indicates that the Notch ligands Delta and Jagged are also substrates for γ-secretase, the intramembrane aspartyl protease responsible for processing of Notch and AβPP...
Lean Mice Live Longer: Does Insulin in Fat Hasten Aging?
Those who can eat as much as they please without gaining avoirdupois may feel smug about a paper in tomorrow’s Science, which reports that mice that lack insulin receptors only in their fat tissue outlive their normal brethren by about 18 percent...
Cholesterol Continued: CYP46 Gene Linked to AD, ApoE
In this week's issue of the Archives of Neurology, collaborators from around Europe propose that a polymorphism in the gene for cholesterol 24-hydroxylase CYP46) is a risk factor for late-onset Alzheimer's...
Mutant AβPP Retards Growth in Hippocampus before Plaques Form
Collaborative research directed by Floyd E. Bloom of Neurome Inc. and the Scripps Research Institute shows that dramatic changes occur in the brains of mice expressing mutant human forms of AβPP long before any Aβ has been deposited...
Homing in on Roles for PS Complex Proteins APH-1 and PEN-2
Two recent papers from the Journal of Biological Chemistry shed additional light on the roles of APH-1 and PEN-2, two proteins that were only last year identified in screens of the roundworm <em>C. elegans</em> and implicated as members of the presenilin (PS) complex...
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