Combining memantine with an older, widely used AD drug further improves measures of cognition, global well-being, activities of daily living, and behavior in people with moderate to severe AD, according to a study published in the January 21 JAMA...
What if all it took was a little sugar—not to make some other medicine go down, but as a therapy in itself for Huntington's disease? This is the promise of an article published...
For several years now, the Alzheimer's research and treatment communities have been awaiting the fruition of promising research into quantitative imaging agents that could signal the presence of amyloid...
Anyone interested in studying aging cells may want to check out today's Nature Genetics, which reports a transcriptome profiling method that identifies age-related patterns in gene expression across different species...
A paper in press in the Journal of Biological Chemistry suggests that sphingolipids, in addition to cholesterol, may play an important role in regulating intramembrane cleavage of amyloid β precursor protein...
This report summarizes some of the genetic findings for late-onset Alzheimer's disease presented last November at the 33rd Annual Meeting of the Society for Neuroscience in New Orleans...
In the current issue of Science, researchers report that CREST—a protein that interacts with CREB (cAMP response element-binding protein) binding protein, or CBP—is required for proper dendritic growth in neurons...
In yesterday’s Neuron, researchers presented fresh in-vivo support for the amyloid hypothesis and bolster the status of the APP protease BACE as the current favorite target for AD therapy development...
Results are in from the first pilot study to test the potential benefit of clioquinol in Alzheimer's disease patients, suggesting that the drug improves cognition and lowers plasma levels of Aβ42 in some patients...
Localized gene transfer has produced the first rat model of neurofibrillary tangles, announce the authors of a report in the January 2004 American Journal of Pathology...
Two recent studies confirm that local inflammation inhibits adult neurogenesis in the hippocampus and, in a promising advance, they find evidence that...
As government officials scramble to contain the current scare over a cow that tested positive for BSE in Washington state earlier this week, researchers in New York and Boston report...
A report in last week's Cell suggests that TGF-β1, one of the three mammalian isoforms of that growth factor, can protect against excitotoxic neurodegeneration...
Scientists prospecting the amyloid hypothesis for new treatment strategies have set their sights on the idea of boosting the enzymatic destruction of the Aβ peptide...