6397 RESULTS
Sort By:
Some foods only reveal their flavor after you add a dash of salt. Similarly, say the authors of an article in the July 18 issue of Science, some genes only show an association with disease when environmental factors are taken into account...
PET Diagnosis Poised for Prime Time? FDA Wants Consensus, Better Trials ApoE Catalyst Conference Explores Drug Development Opportunities Institute for the Study of Aging Symposium
The proteasome, that large subcellular grinder that recycles protein, plays a major role in localized degeneration of axons, according to a report in this week's Neuron. Such neuronal damage typically follows traumatic injury, but it can also be caused by...
On May 29 and 30, the New York City-based <a href="http://www.aging-institute.org/venture.htm">Institute for the Study of Aging</a> convened a small symposium to take the pulse of current research on ApoE, the leading risk factor for nonfamilial AD...
In this week’s Neuron, researchers report that polyglutamine-expanded huntingtin (Htt)—the direct cause of Huntington's disease—exacerbates inositol triphosphate-mediated calcium signaling...
Human tau—whether normal or a disease-causing mutant—does not make for a healthy <em>C. elegans</em>. In the Early Edition of PNAS, Gerry Schellenberg and colleagues report that both types of transgenic tau lead to behavioral, synaptic, and pathologic abnormalities in the worms...
Tao et al. and Honbou et al. recently reported the crystal structure of DJ-1 at resolutions of 1.8 and 1.95 Ångstroms, respectively (see <a href="/news/research-news/spotlight-dj-crystal-structure-solved-parkinsons-protein">ARF related news story</a>), but the latest report by Greg Petsko and colleagues in the July 10 PNAS Early Edition online, tops that by almost another Ångstrom.
A report in this week's PNAS suggests that neurogenesis can occur in response to neurodegeneration in human brains. Principal author Richard Faull and colleagues at the University of Auckland, New Zealand, report that significantly more neuronal proliferation occurs...
Recent evidence has enhanced the image of astrocytes, suggesting these glial cells are a source for stem cells, and that they mop up Aβ. But online publications in this week's PNAS and Nature Neuroscience indicate that astrocytes also are a major impediment to...
Just grind some dehydrated blueberries into your people-chow and counteract the effects of aging and Alzheimer's disease on memory. That's one hypothesis we can take away from a recent study by Jim Joseph and colleagues...
In Alzheimer's disease (AD), the first significant damage to neurons may be the loss of proteins involved in long-term potentiation (LTP) and memory. So conclude Dave Morgan and colleagues from the University of South Florida, Tampa, and Incyte Genomics, Palo Alto, California, in the June 15 Journal of Neuroscience...
Seeing Alzheimer’s: Advances in Brain Mapping Bring Goal a Step Closer Organization for Human Brain Mapping 2003 Annual Meeting
I-han Chou reports from Brain Mapping Conference in New York City.
Synapses—those specialized junctions that facilitate transmission of action potentials between neurons—are composed of a myriad of highly sophisticated proteins. Some, like neurexins, have yet to be fully characterized...
In this month's Nature Cell Biology, Frank Lezoualc'h and colleagues at the University of South Paris report that serotonin, or 5-hydroxy tryptamine (5HT), mediates sAPPα release through a cyclic AMP (cAMP) signaling pathway independent of protein kinase A (PKA)...
