Parkinson's Proteins and the Proteasome—The Plot Thickens
Read about this latest study linking α-synuclein and parkin to proteasomal degradation, this time addressed in vitro with proteasome inhibitors.
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Dendritic Spine Stability—Not So Black and White—or Is That Green and Yellow?
Dendritic spines—tiny protrusions that mediate synaptic contacts between neurons—are present in vast numbers in the mammalian brain (up to ten thousand per neuron)...
Amyloid Formation—One Amino Acid Can Make a Difference
In Alzheimer's brains there exists a complex, dynamic equilibrium among the various soluble and fibrillar forms of the Aβ protein...
Gabrielle Strobel Interviews Susan Lindquist
Susan Lindquist and colleagues published two papers in Science last month, which provide the backdrop and introduction to this interview.
Making Light of Apoptosis
In Alzheimer's, as in many other neurodegenerative diseases, neurons often meet their demise after apoptotic, or programmed cell death pathways have been activated...
Human "Kinome" Mapped
Researchers from the biotechnology company SUGEN (a subsidiary of Pharmacia Corporation) and the Salk Institute in La Jolla, California, report that they have mapped all 518 protein kinases in the human genome...
New Insights into Fibril Formation
Two papers in PNAS add to the growing body of work aimed at understanding the molecular interactions involved in the formation of amyloid fibrils...
Aβ Elevated in Endothelin Converting Enzyme Knockouts
In the December 2 online Journal of Biological Chemistry, researchers extend to mice earlier in-vitro observations linking Aβ degradation to the activity of endothelin converting enzyme (ECE)...
Playing Sonic Hedgehog in the Hippocampus
The developmental signaling protein sonic hedgehog (Shh) appears to play a significant role in regulating the proliferation of adult stem cells, according to a report in yesterday’s Nature Neuroscience...
Protein Folding Alert: Good Writeup by Chris Dobson
Are you are curious about protein folding and how this fundamental process might go awry in diseases such as Alzheimer’s? If so, you may enjoy reading...
Join the Quantum Dots—for Brighter, Longer, and Multiplex Cell Images
Scientists keen on monitoring cellular events in real time can now add another imaging technique to their repertoire—the use of quantum dots...
Neurons See the Light—and Move toward It
We all know that plants grow toward a light source—but would you believe the same of neurons? Neuronal "phototropism" is exquisitely demonstrated by a report published online in last week's PNAS...
No Junk After All: Dinucleotide Repeats Change eNOS Splicing; What about AD?
Dinucleotide repeats are scattered throughout the human genome, but do they actually do anything? A report in yesterday's Nature Structural Biology reveals that in some cases at least...
International Conference on Alzheimer's Disease 2002
Stockholm: Visualizing Amyloid Biggest Draw at Imaging Symposium, Consensus Sought on Validation Stockholm: Chlamydia Triggers Amyloid Plaques in Mice Stockholm: Aph-1 and Pen-2: New Names in the Presenilin Debate Complete the Complex? Stockholm: Clusteri
Society for Neuroscience Annual Meeting 1998
1998 Society for Neuroscience Meeting: α2-Macroglobulin 1998 Society of Neuroscience Meeting: AD Plaques Associated with Curvier Dendrites 1998 Society for Neuroscience Meeting: Aβ vs. APP Effects in Transgenics 1998 Society for Neuroscience Meeting: Fram
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