APP and Axonal Transport: A Report from Bar Harbor
It is widely accepted that at least a fraction of APP is actively transported along the axon to the nerve terminal and does not return to the cell body.
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It is widely accepted that at least a fraction of APP is actively transported along the axon to the nerve terminal and does not return to the cell body.
After release, some Aβ is degraded locally, a second fraction leaves the brain through interstitial fluid drainage and along brain arterioles, while another fraction is actively transported by proteins, such as LRP and glycoprotein-P, across the blood-brain barrier (BBB) into systemic circulation.
Clearly, the greatest risk factor for AD is advanced age, but a satisfying explanation of the link between aging and AD remains uncertain. To understand this connection, it is argued that a better understanding of "normal" aging is needed.
This workshop has an enduring interest in facilitating the import into AD research of new technologies developed in other areas. This year an approach was presented that makes it possible to watch neurons grow and change over time inside living mice.
Recommendations for future research following the Enabling Technologies for Alzheimer's Disease Workshop in Bar Harbor, ME
APP Function: A Report from Bar Harbor APP and Axonal Transport: A Report from Bar Harbor BBB/Brain Vasculature: A Report from Bar Harbor Aging and AD: A Report from Bar Harbor Enabling Technologies: A Report from Bar Harbor Recommendations: A Report from
This report summarizes discussions and recommendations made at the fourth annual workshop on Enabling Technologies for Alzheimer's disease (AD), held in August 2004 in Bar Harbor, Maine.
Major points of discussion and ideas for future directions from the Enabling Technologies for Alzheimer's Disease 2004 Workshop in Bar Harbor, Maine.
This is a list of final recommendations for future actions from the Enabling Technologies for Alzheimer's Disease Workshop in Bar Harbor, Maine.
Enabling Technologies 2004 Workshop Summary Major Points of Discussion and Ideas for Future Directions List of Final Recommendations from Bar Harbor Enabling Technologies for Alzheimer Disease Research: 2004 Bar Harbor Workshop
The first day of Enabling Technologies 2003 focused on the natural history of Alzheimer's disease, fundamental cell biology, and mechanisms of neurodegeneration.
Recommendations for future research from the Enabling Technologies for Alzheimer's Disease Workshop in Bar Harbor, Maine.
Enabling Technologies 2003 Workshop Summary Recommendations: A Report from Bar Harbor 2003 Enabling Technologies for Alzheimer Disease Research: 2003 Bar Harbor Workshop
Scientists report a case of identical twins with the C9ORF72 DNA expansion—only one has ALS.
More than half of dementia patients near the end of life receive medications that may not help them, according to an analysis of U.S. nursing home data.