Though no one is exactly sure why, loss of the ubiquitin carboxy terminal hydrolase UCHL1 appears to be linked to both Alzheimer and Parkinson disease. Now, a paper in this week’s PNAS online raises the intriguing possibility that...
Two years ago, researchers succeeded in breeding fruit flies with mutations in parkin, the gene responsible for most cases of early-onset PD in humans...
In a brief article in today’s Science, Frederic Mery and Tadeusz Kawecki at the University of Fribourg, Switzerland, report that in fruit flies, at least, making...
Dogma holds that presenilins in the γ-secretase complex beget amyloid-β (Aβ) peptides by cleaving the membrane-bound β amyloid precursor protein (AβPP). But new results show...
Mutant proteins that cause neurodegenerative disease, such as amyloid-β precursor protein, parkin, and huntingtin, are produced in many different neurons of the brain. So why do only...