In a sparsely attended slide presentation yesterday at the Neuroscience meeting, <strong>Inez Vincent</strong> of the University of Washington, Seattle, presented a feat no one seems to have pulled off before...
In the field’s current focus to understand what might go wrong at synapses early on in AD, measuring long-term potentiation has become a widely applied tool...
Today at the annual meeting of the Society for Neuroscience, <strong>Lee Goldstein</strong> of Massachusetts General Hospital presented evidence suggesting that the Aβ peptide occurs in the eyes of people with Alzheimer’s disease...
Aβ levels and amyloid plaque load can be reduced significantly in animal models of Alzheimer's disease by interfering—either genetically or pharmacologically—with the immunoregulatory molecule CD40 ligand...
Today at the Society for Neuroscience Conference, <strong>Ross Bland’s</strong> poster about a new rat model for the study of Alzheimer’s disease drew quite a crowd...
As the amyloid pathology is shifting away from blaming predominantly amyloid plaques to now pointing a second accusing finger to smaller, non-deposited aggregates of the Aβ peptide...
Regulated intramembranous proteolysis, RIP for short, denotes an unusual way of cutting proteins lodged in a membrane right inside their membrane-spanning parts...
It would seem intuitively appealing that the brain’s billions of minuscule information exchanges—the synapses—may be the main site of destruction in Alzheimer’s disease...
The low-density lipoprotein receptor-related protein, or LRP for short, is part of a family of receptors that mediate the uptake and destruction of extracellular molecules including apolipoprotein E. Previous in vitro experiments have shown...
The proteolytic degradation that accompanies neurodegeneration in animals may be mediated not by apoptotic proteases, but by a group of aspartyl and calcium-dependent proteases, at least in the roundworm, researchers report in today's Nature...
Crumbling microtubules, those slender filaments that aid a variety of cellular processes from cell division to vesicle trafficking, could lead to motor neuron disease...
Evidence has grown over the last few years for the involvement of the tumor suppressor protein p53 in the neuronal cell death that accompanies a variety of neurodegenerative diseases, including Alzheimer's disease...