Ipsen Colloquium on Alzheimer’s Disease 2003
Bill Klunk Reports from Paris on The Living Brain and Alzheimer’s Disease Ipsen Colloquium on Alzheimer’s Disease 2003
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Astrocytes—Part of the Solution or Part of the Problem?
While recent evidence suggests that astrocytes may help degrade β amyloid, a report in the March 7 online Journal of Biological Chemistry suggests they may also help produce it...
Breaking Away: Human Glial Stem Cells Generate Neurons
The stem cells populating the white matter tracts in human brain can generate neurons, apparently just by being removed from an environment that limits them to a glial fate...
Huntingtin Partner Sp1 Prevents Death by Oxidation
Oxidative stress has been implicated as a factor in the neurodegeneration that leads to a variety of neurologic disorders, including Parkinson's and Huntington's diseases...
New Parkinson's Fly Can’t Fly, Implicating Mitochondria
Mitochondrial malfunction underlies the pathological damage seen in fruit fly models of Parkinson's disease, researchers report in this week's PNAS online. The paper adds to the growing body of evidence linking this intracellular organelle to neurodegeneration...
David Holtzman and Ashley Bush Win 2003 Potamkin Prize
One of the most prestigious honors for researchers in Alzheimer’s, Niemann-Pick disease, and related disorders this year went jointly to David Holtzman of Washington University, St. Louis, Missouri, and Ashley Bush of Massachusetts General Hospital in Charlestown...
Smells Like Neuronal Proliferation!
A cytokine called leukemia inhibitory factor (LIF) plays a critical role in adult neurogenesis in the olfactory bulb in vivo, according to a report in the current Journal of Neuroscience...
Following Footsteps of AD Vaccination: Passive Shots Against Prions Protect Mice
Passive antibody immunization against prion protein prevents the spread of clinical disease to the brain of mice, even though the antibody works primarily by reducing prion replication in peripheral tissues, including the spleen. This is the astonishing news in a report in today’s Nature...
New Players on the Parkinson's Field
Two research groups at Columbia University's Taub Institute have discovered new molecular partners for parkin and α-synuclein—proteins that, when mutated, cause early-onset familial forms of Parkinson's disease...
Got Plaques? Astrocytes to the Rescue!
Astrocytes may play an active role in degrading amyloid-β (Aβ), the peptide found in the amyloid plaques that clog the intracellular space in the brains of people with Alzheimer's disease...
Mean Life Expectancy 112?
There may be no Shangri-La or fountain of eternal youth, but that does not stop scientists from searching for that biochemical reaction or signal transduction pathway that may hold the key to a longer and healthier "old age."
Aβ, Shifty Drifter? Tissue Grafting Sheds Light on Plaque Formation
An article in the February 24 Nature Neuroscience online suggests that amyloid-β (Aβ), the peptide responsible for the intercellular plaques that appear in the brains of Alzheimer's patients, can freely diffuse through neural tissue, and that it plays a major role in the pathogenesis of the disease...
Viral Transgene Models Parkinson's in Primate
Last year, three separate laboratories managed to create impressive Parkinson's disease models by transferring human α-synuclein via viral vectors to mice. This approach has now panned out in a primate model...
Picking Apart Disorders of Cholesterol Metabolism
Two papers published in the 18 February online edition of PNAS reveal structural features that help explain the function of the proposed cholesterol-binding protein NPC2...
Playing "Gotcha" with the Phantom: α-synuclein Oligos Spotted in Vivo
In today’s Neuron, scientists at Brigham and Women’s Hospital in Boston, Massachusetts, report that they have devised a biochemical strategy to detect the earliest aggregates of the protein α-synuclein in cultured neurons, mouse brain, and human brain...
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