The APPsw Mouse Links ApoE to Damaged Neurons
Further evidence that apoE is needed for deposition of the fibrillar form of Aβ in plaques was presented today at the American Neurological Association's annual meeting in Seattle today...
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Familial Dementia Linked to Neuroserpin Aggregation
Protein misprocessing and aggregation have been observed in many neurodegenerative diseases, including Alzheimer’s, spongiform encephalopathies, Huntington’s, Parkinson’s and FTDP-17, but it has been difficult...
Can Age-Related Memory Decline Be Reversed?
Writing in the current Nature Neuroscience, Heather Cameron and Ronald D.G. McKay report that they were able to boost the rate of neurogenesis in the hippocampus of aging rats by lowering corticosteroid levels...
APP Has a Role in Synaptic Development
In today's Journal of Neuroscience, Vivian Budnik, Laura Torroja, and their colleagues provide evidence that under normal circumstances, APP is a critical player in the formation and maintenance of synapses...
How to Misfold a Prion Protein
In the current Nature Cell Biology, Susan Lindquis and Jiang Ma of the Howard Hughes Institute at the University of Chicago report that they were able to produce abnormal prion protein (PrP) conformations from normal PrP...
Aβ and Tau Accumulation in an Animal Model of Brain Trauma
Douglas Smith and his colleagues at the University of Pennsylvania may have filled a gap in research on long-term, neurodegeneration sequelae of brain injuries...
TNF-α Reveals Another Deadly Trick
If the inflammatory cytokine tumor necrosis factor α (TNF-α) is at work in Alzheimer's disease, it may not be relying on its well-described, directly apoptotic mechanism to cause problems...
AD Mouse Model with Whole APP and PS-1 Genes
In the August issue of Nature Neuroscience, Bruce Lamb and his associates at Case Western report that they have transferred complete copies of genes for mutant human APP and PS-1 into mice that subsequently...
DNA Damage Surveillance after Head Injury
Various recent studies have reported a link between head trauma and and an increased risk of Alzheimer's disease, but why this might be has been a matter of speculation...
Vaccinating Against Plaques
Findings reported in tomorrow’s issue of Nature raise the tantalizing possibility of using vaccination to prevent or ameliorate Alzheimer’s disease. In the study, by Dale Schenk and colleagues at Elan Pharmaceuticals...
For Lack of a Stop Codon
In tomorrow's issue of Nature, Jorge Ghiso and colleagues at New York University, and coworkers at the National Hospital for Neurology and Neurosurgery in London, report that they have found the gene mutation that produces the amyloid in Familial British Dementia (FBD)...
PIN1 Restores Phosphorylated Tau Function
In tomorrow’s issue of Nature (pp. 784-788), Kun Ping Lu of Harvard Medical School and colleagues report that an enzyme, prolyl isomerase Pin1, binds to phosphorylated tau from Alzheimer’s patients...
Novel APP-p53 Interaction Found
Neurons taken from the brains of deceased Alzheimer's patients exhibit markers for apoptosis, but little is known about what induces the expression of apoptotic genes...
The AMPA Receptor Steps out of the Shadows
Researchers studying the molecular basis of long-term potentiation (LTP) have typically focused on the role of NMDA glutamate receptor, but two papers published in the June 11 issue of Science elucidate the role of the other glutamate receptor, the AMPA receptor...
Human ApoE3, but Not ApoE4, Protects Neurons in the ApoE Knockout Mice
A 1997 study indicated that Alzheimer's patients who carried one or both alleles that code for the E4 form of apolipoprotein had more severe neurodegeneration than did patients who carried only alleles coding for the E3 form of the protein...
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