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One of the first symposia of the conference was dedicated to an overview of the current and future treatments for AD. Six presenters gave their perspectives on many treatment issues...
Amyloid plaques are still the main attraction, and tangles have certainly not left the stage, but there is still a lot of interest at this meeting (off-Broadway, so to speak) in other potential players in AD pathology...
The editors of the Journal of Alzheimer Disease announced today that Suzanne de la Monte was the recipient of its Alzheimer Medal for best article published in the past year...
Transplanted stem cells have provided compelling news stories in recent years, promising regeneration of damaged nervous systems, but another possibility—that the adult brain itself could provide the pluripotent cells...
One of the challenges to diagnosing Alzheimer's disease is the lack of a nonbehavioral clinical test. The definitive diagnosis can only be made when amyloid plaques and neurofibrillary tangles are seen at autopsy...
Finding a safe way to get therapeutic genes past the blood-brain barrier has led to some interesting approaches using the barrier's own transport systems to shuttle DNA across the blood capillary wall...
Results presented by three research groups this week all confirm that presenilin is, at the least, essential for γ-secretase to cleave amyloid precursor protein in the process that releases amyloid-β-...
The discovery that Huntington's disease results from a particular mutation of the gene for the protein dubbed "huntingtin" has created great hope that this neurodegenerative movement disorder will soon have effective treatments...
How are short-term memories converted to long-term memories? The process is certain to be complex, and a study in the 23 June issue of Science suggests thetranscription factor NPAS2 may play an important role...
Peter Lansbury, like I and others, has long promulgated the idea that intermediates in CNS disease-related fibrillogenesis processes are likely to be pathogenic, whereas mature matted fibrils (although not desirable) are relatively inert...
Last July, Dale Schenk and colleagues from Elan Pharmaceuticals reported the remarkable observation that simple immunization of PDAPP transgenic mice...
Creatine, increasingly popular as a dietary and exercise supplement, has shown the ability to counteract laboratory models of amyotrophic lateral sclerosis, Huntington's disease, and Parkinson's disease...
The true identity of γ-secretase, the enzyme that frees amyloid-β from its membrane-bound precursor, is one of the holy grails in the search for the cause of Alzheimer's disease...
The cysteine protease calpain cleaves the cdk5 regulator p35, releasing a 25KD fragment that accumulates in the brains of people with Alzheimer’s disease. What’s more, Aβ42 is among the factors...
According to a report in today's Science, a productive approach to combating the spongiform encephalopathies such as the transmissible "variant" Creutzfeldt-Jacob disease may be to attack cells in the spleen where...
