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For several neurodegenerative diseases, scientists identified which cell types exert a person’s inherited risk. In Alzheimer’s, it’s microglia; in Parkinson’s, it’s dopaminergic and enteric neurons—and oligodendrocytes.
Brain imaging and cognitive tests may be the gold standards for tracking AD progression, but clinical trials using these procedures are expensive, risky, and time-consuming...
Risk alleles of SORL1 dampen its expression in response to growth factors, leading to higher Aβ production.
Scientists have produced an atomic-level picture of a receptor implicated in both the sporadic and familial forms of Alzheimer’s.
It’s not just for tugging APP around the neuron: The SORLA receptor may also bind Aβ and hasten its demise.
Two papers published this month claim to identify those at greatest risk for Alzheimer’s disease and illuminate the mechanisms behind it...
Scientists are discovering just how intimately involved lipoprotein receptors are in the care and maintenance of neurons and their synapses...
Progranulin, a raw form of granulin (GRN), landed center stage of neurodegeneration research four years ago...
For years there has been a somewhat murky connection between Alzheimer disease and cerebrovascular disease...
The sorting receptor SorLA is thought to...
The completion of the human genome sequence brought renewed hope that genetic causes and susceptibilities to disease could be identified...
This week, a study previously reported in our Conference News appeared in PNAS. In it...
Trialists are shooting new arrows at the disease, including compounds that tweak autophagy, neuroinflammation, and glycolipid recycling.
In a preliminary study, 15 percent of people with ALS had antibodies against an enzyme that processes the wheat protein gluten.
At an NIH conference in Washington, D.C., experts from beyond Alzheimer’s research discussed ways to beef up data collection and patient participation.
